低压环境应激对大鼠酪氨酸转氨酶和苯丙氨酸4-羟化酶活性的影响。
Effect of environmental stress of low pressure on tyrosine aminotransferase and phenylalanine 4-hydroxylase activities in the rat.
作者信息
Namboodiri M A, Ramasarma T
出版信息
Biochem J. 1975 Aug;150(2):263-8. doi: 10.1042/bj1500263.
Abstract
- Tyrosine aminotransferase activity in the liver increased about fourfold after 9h, on exposure of rats to stress of low pressure. 2. The phenylalanine hydroxylase activity increased about 60% on exposure for 24h or more. 3. An environmental pressure decrease of about 0.033 MN/m2 is needed to increase the activity of tyrosine aminotransferase. 4. Adrenalectomy completely abolished the increase in activity of tyrosine aminotransferase obtained on exposure to low pressure. 5. Treatment with cycloheximide or actinomycin D prevented the increase in activity of tyrosine aminotransferase. 6. Treatment with cycloheximide at the early part of exposure to stress prevented the increase in activity of phenylalanine hydroxylase obtained after 24h.
摘要
- 将大鼠置于低压应激环境中9小时后，肝脏中的酪氨酸转氨酶活性增加了约四倍。2. 暴露24小时或更长时间后，苯丙氨酸羟化酶活性增加约60%。3. 需要约0.033 MN/m2的环境压力降低才能增加酪氨酸转氨酶的活性。4. 肾上腺切除术完全消除了暴露于低压时酪氨酸转氨酶活性的增加。5. 用环己酰亚胺或放线菌素D处理可阻止酪氨酸转氨酶活性的增加。6. 在应激暴露初期用环己酰亚胺处理可阻止24小时后获得的苯丙氨酸羟化酶活性的增加。
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