Roseboom H, Förch A D
J Pharm Sci. 1979 Apr;68(4):515-7. doi: 10.1002/jps.2600680435.
The degradation kinetics of 10-acetylphenothiazine were studied after isolation and identification of its degradation products, phenothiazine, phenothiazine-5-oxide, 3H-phenothiazine-3-one, and 7-(10'-phenothiazinyl)-3H-phenothiazine-3-one. The acetyl group was not present in any degradation product. The degradation rate was independent of oxygen but highly pH dependent, indicating a specific hydrogen-ion-catalyzed hydrolysis of 10-acetylphenothiazine to give phenothiazine, which was oxidized. The experimental values for the phenothiazine concentration were in good agreement with values calculated on the basis of this assumption, both in the presence and absence of oxygen.
在分离并鉴定了10-乙酰吩噻嗪的降解产物吩噻嗪、吩噻嗪-5-氧化物、3H-吩噻嗪-3-酮和7-(10'-吩噻嗪基)-3H-吩噻嗪-3-酮之后，对10-乙酰吩噻嗪的降解动力学进行了研究。在任何降解产物中均未发现乙酰基。降解速率与氧气无关，但高度依赖于pH值，这表明10-乙酰吩噻嗪发生了特定的氢离子催化水解反应生成吩噻嗪，而吩噻嗪被氧化。无论是在有氧还是无氧条件下，吩噻嗪浓度的实验值与基于该假设计算出的值都非常吻合。
