Roseboom H, Perrin J H
J Pharm Sci. 1977 Oct;66(10):1392-5. doi: 10.1002/jps.2600661010.
The rate of phenothiazine degradation in an acidic oxygen-saturated medium was studied. 3H-Phenothiazine-3-one and phenothiazine 5-oxide are produced by parallel reactions, and 7-(10'-phenothiazinyl)-3H-phenothiazine-3-one is produced in a more complex manner. The overall phenothiazine degradation rate appears to be pH independent up to pH 7.0. The degradation kinetics of 10-methylphenothiazine were studied after isolation and identification of its degradation products, 10-methylphenothiazine 5-oxide and 3H-phenothiazine-3-one. The main degradation product is 10-methylphenothiazine 5-oxide; but at low pH values and high temperatures, more 3H-phenothiazine-3-one is formed. The degradation rate of 10-methylphenothiazine is pH independent up to pH 7.
研究了吩噻嗪在酸性氧饱和介质中的降解速率。3H-吩噻嗪-3-酮和吩噻嗪5-氧化物通过平行反应生成，7-(10'-吩噻嗪基)-3H-吩噻嗪-3-酮以更复杂的方式生成。在pH值高达7.0时，吩噻嗪的总体降解速率似乎与pH无关。在分离并鉴定了10-甲基吩噻嗪的降解产物10-甲基吩噻嗪5-氧化物和3H-吩噻嗪-3-酮后，研究了其降解动力学。主要降解产物是10-甲基吩噻嗪5-氧化物；但在低pH值和高温下，会生成更多的3H-吩噻嗪-3-酮。在pH值高达7时，10-甲基吩噻嗪的降解速率与pH无关。
