Drug absorption from in situ rat small intestine during metoclopramide administration.

The effect of metoclopramide on the absorption of drugs in solution in the small intestinal lumen of rats in situ was studied. Metoclopramide in doses up to 50 mg/kg sc did not significantly modify the disappearance of isoniazid and quinidine from the small intestinal lumen. At the end of the absorption experiments, quinidine in the whole blood of the experimental animals was increased after metoclopramide. The blood level did not correlate to the drug disappearance from the intestinal lumen. The results probably differ from those obtained when drugs are given orally to subjects treated with metoclopramide.