甲氧氯普胺可减少人体对碳水化合物的吸收。
Metoclopramide reduces carbohydrate absorption in man.
作者信息
Holgate A M, Read N W
出版信息
Br J Clin Pharmacol. 1985 Jan;19(1):67-72. doi: 10.1111/j.1365-2125.1985.tb02614.x.
The effect of metoclopramide (20 mg p.o) on the times taken for a radiolabelled liquid starch meal to empty from the stomach and to reach the ileum (230 cm from the mouth), the ileal flow rates and the degree of carbohydrate absorption were studied in five normal male volunteers, intubated with a four lumen intestinal tube. Administration of metoclopramide significantly reduced the time taken for delivery of 50% and 80% of the meal to the ileal aspiration site, but had no significant effect on the half time for gastric emptying. Administration of metoclopramide did not affect the average flow rate or the total postprandial volume, which passed the ileal aspiration site. Administration of metoclopramide reduced carbohydrate absorption in every subject by between 8 and 30%. This study is consistent with the hypothesis that metoclopramide may reduce the degree of absorption in the human small intestine by decreasing the contact time between food and small intestinal epithelium, though it could also act by reducing the area of mucosa in contact with nutrients.
在5名通过四腔肠管插管的正常男性志愿者中，研究了胃复安（口服20毫克）对放射性标记的液体淀粉餐从胃排空并到达回肠（距口腔230厘米处）所需时间、回肠流速以及碳水化合物吸收程度的影响。给予胃复安显著缩短了50%和80%的餐食到达回肠抽吸部位所需的时间，但对胃排空的半衰期没有显著影响。给予胃复安对通过回肠抽吸部位的平均流速或餐后总体积没有影响。给予胃复安使每个受试者的碳水化合物吸收减少了8%至30%。这项研究与以下假设一致，即胃复安可能通过减少食物与小肠上皮之间的接触时间来降低人体小肠的吸收程度，尽管它也可能通过减少与营养物质接触的黏膜面积起作用。
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