Yoshida N, Tanaka C, Taniyama K, Kondo M
Jpn J Pharmacol. 1979 Oct;29(5):781-7. doi: 10.1254/jjp.29.781.
Age-related changes in cyclic adenosine 3',5'-monophosphate levels in response to norepinephrine (NE) in the rectum of postnatal rats and the localization of cyclic AMP in the rectum were studied. During the first 2 weeks after birth, the basal levels of cyclic AMP were high, NE responses to cyclic AMP contents were minimal and thereafter, the basal cyclic AMP levels rapidly declined, while NE response significantly increased compared to those seen in tissues from adult rats. Furthermore, cyclic AMP immunofluorescence was visualized in smooth muscle and postganglionic neurons of the myenteric plexus. NE application produced an increase of cyclic AMP immunofluorescence in smooth muscle. These results indicate that NE response to cyclic AMP levels in rat rectum is age-dependent and suggest that the majority of beta-adrenoceptors associated with cyclic AMP generating system are localized in the smooth muscle of rat rectum.
研究了出生后大鼠直肠中环磷酸腺苷（cAMP）水平对去甲肾上腺素（NE）反应的年龄相关变化以及cAMP在直肠中的定位。出生后的前2周，cAMP的基础水平较高，NE对cAMP含量的反应最小，此后，基础cAMP水平迅速下降，而与成年大鼠组织相比，NE反应显著增加。此外，在肌间神经丛的平滑肌和节后神经元中观察到cAMP免疫荧光。应用NE可使平滑肌中的cAMP免疫荧光增加。这些结果表明，大鼠直肠中NE对cAMP水平的反应具有年龄依赖性，并提示与cAMP生成系统相关的大多数β-肾上腺素能受体定位于大鼠直肠的平滑肌中。
