Godfrey S, Bolton D P, Cross K W
Br Med J. 1970 Feb 21;1(5694):475-7. doi: 10.1136/bmj.1.5694.475.
The effects of two analeptic drugs-taloximine and ethamivan-have been studied in asphyxiated fetal and newborn rabbits. In primary apnoea ethamivan reduced the time before the onset of gasping, while during gasping taloximine increased the gasp rate. In secondary apnoea neither drug initiated respiration, though most animals could be resuscitated by using intermittent positive pressure respiration. From these results it is suggested that analeptic drugs have no place in obstetric or neonatal departments.
已经在窒息的新生兔和胎儿兔身上研究了两种苏醒药——他洛昔明和香草二乙胺的效果。在原发性呼吸暂停时，香草二乙胺缩短了喘息开始前的时间，而在喘息期间，他洛昔明提高了喘息频率。在继发性呼吸暂停时，这两种药都不能引发呼吸，不过大多数动物可以通过间歇性正压呼吸复苏。从这些结果来看，苏醒药在产科或新生儿科没有用武之地。
