Chernick V, Madansky D L, Lawson E E
Pediatr Res. 1980 Apr;14(4 Pt 1):357-9. doi: 10.1203/00006450-198004000-00021.
Naloxone, a specific opiate antagonist with no agonist properties, in doses of 0.4 and 4.0 mg/kg was found to markedly reduce the duration of primary apnea in asphyxiated newborn rabbits. There was no effect on the duration of the hyperpneic phase (time to primary apnea) or on survival time (time to last gasp). It is suggested that endogenous opiate-like peptides are released during asphyxia and are the major factor in the suppression of medullary inspiratory neuronal discharge during primary apnea.
纳洛酮是一种无激动剂特性的特异性阿片拮抗剂，研究发现，剂量为0.4毫克/千克和4.0毫克/千克的纳洛酮能显著缩短窒息新生兔原发性呼吸暂停的持续时间。对呼吸增强期的持续时间（至原发性呼吸暂停的时间）或存活时间（至最后喘息的时间）没有影响。研究表明，内源性阿片样肽在窒息过程中释放，是原发性呼吸暂停期间抑制延髓吸气神经元放电的主要因素。
