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相似文献

1
Elongation of fatty acids in Mycobacterium tuberculosis.结核分枝杆菌中脂肪酸的延长
J Bacteriol. 1970 Mar;101(3):781-5. doi: 10.1128/jb.101.3.781-785.1970.
2
Direct incorporation of octanoate into long-chain fatty acids by soluble enzymes of Mycobacterium tuberculosis.结核分枝杆菌可溶性酶将辛酸直接掺入长链脂肪酸中。
Biochim Biophys Acta. 1965 Jun 1;98(3):476-85. doi: 10.1016/0005-2760(65)90144-x.
3
Characterization of the fatty acid elongation system in soluble extracts and membrane preparations of rat liver mitochondria.大鼠肝脏线粒体可溶性提取物和膜制剂中脂肪酸延长系统的特性分析。
J Biol Chem. 1969 Dec 10;244(23):6432-43.
4
Fatty acid biosynthesis in Erlich cells. The mechanism of short term control by exogenous free fatty acids.艾氏腹水癌细胞中的脂肪酸生物合成。外源性游离脂肪酸的短期调控机制。
J Biol Chem. 1975 Jul 25;250(14):5419-25.
5
Fatty acid synthesis by chain elongation in rat-liver mitochondria.大鼠肝脏线粒体中通过链延长进行脂肪酸合成。
Biochim Biophys Acta. 1968 Sep 2;164(1):12-24. doi: 10.1016/0005-2760(68)90066-0.
6
De novo fatty acid synthesis and elongation of fatty acids by subcellular fractions of lung.肺亚细胞组分进行的脂肪酸从头合成及脂肪酸延长过程。
J Lipid Res. 1971 Mar;12(2):248-55.
7
Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp.高等植物中的脂肪代谢。鳄梨成熟中果皮可溶性制剂对脂肪酸的β-羟基化作用。
Biochem J. 1972 Dec;130(4):1013-8. doi: 10.1042/bj1301013.
8
Characterization of the fatty acid-sensitive glucose 6-phosphate dehydrogenase from Pseudomonas cepacia.洋葱伯克霍尔德菌中脂肪酸敏感的葡萄糖-6-磷酸脱氢酶的特性分析。
J Bacteriol. 1977 Nov;132(2):555-63. doi: 10.1128/jb.132.2.555-563.1977.
9
Biosynthesis of branched long-chain fatty acids from the related short-chain -keto acid substrates by a cell-free system of Bacillus subtilis.枯草芽孢杆菌无细胞系统从相关短链β-酮酸底物生物合成支链长链脂肪酸
Can J Microbiol. 1973 Jan;19(1):87-96. doi: 10.1139/m73-013.
10
Chain elongation of fatty acids by cell-free extracts of epidermis from pea leaves (pisum sativum).豌豆叶（豌豆）表皮无细胞提取物对脂肪酸的链延长作用。
Biochem Biophys Res Commun. 1972 Jan 31;46(2):801-7. doi: 10.1016/s0006-291x(72)80212-2.

引用本文的文献

1
Effect of growth temperature on the fatty acid composition of Mycobacterium phlei.生长温度对草分枝杆菌脂肪酸组成的影响。
Arch Microbiol. 1993;159(2):119-23. doi: 10.1007/BF00250270.
2
The positional distribution of fatty acids in the phospholipids and triglycerides of Mycobacterium smegmatis and M. bovis BCG.耻垢分枝杆菌和卡介苗的磷脂及甘油三酯中脂肪酸的位置分布
Lipids. 1970 Aug;5(8):684-91. doi: 10.1007/BF02531435.
3
Intermediary metabolism of mycobacteria.分枝杆菌的中间代谢
Bacteriol Rev. 1972 Mar;36(1):65-108. doi: 10.1128/br.36.1.65-108.1972.
4
Mycobacterial lipids: selected topics.分枝杆菌脂质：选定主题。
Bacteriol Rev. 1972 Mar;36(1):33-64. doi: 10.1128/br.36.1.33-64.1972.
5
Mycobacterium.分枝杆菌属
Bacteriol Rev. 1977 Mar;41(1):217-372. doi: 10.1128/br.41.1.217-372.1977.

本文引用的文献

1
Degradation of labeled propionic and acetic acids.标记的丙酸和乙酸的降解
Arch Biochem Biophys. 1951 Sep;33(2):173-8. doi: 10.1016/0003-9861(51)90094-x.
2
FAT METABOLISM IN HIGHER PLANTS. XXII. ENZYMIC SYNTHESIS OF 14-HYDROXY-11-EICOSENOIC ACID BY PARTICULATE PREPARATIONS OF AVOCADO MESOCARP.高等植物中的脂肪代谢。二十二。鳄梨中果皮微粒体制剂对14-羟基-11-二十碳烯酸的酶促合成
Biochim Biophys Acta. 1965 Feb 1;98:27-35.
3
SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. II. THE OCCURRENCE AND BIOSYNTHESIS OF CIS-VACCENIC ACID.动物组织中脂肪酸的合成。II. 顺式- vaccenic酸的存在与生物合成。
J Biol Chem. 1964 Aug;239:2489-95.
4
SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. I. INCORPORATION OF C14-ACETYL COENZYME A INTO A VARIETY OF LONG CHAIN FATTY ACIDS BY SUBCELLULAR PARTICLES.动物组织中脂肪酸的合成。I. 亚细胞颗粒将C14 - 乙酰辅酶A掺入多种长链脂肪酸中。
J Biol Chem. 1963 Oct;238:3216-23.
5
Enzyme systems in the mycobacteria. 14. Fatty acid synthesis in cell-free extracts of Mycobacterium tuberculosis.分枝杆菌中的酶系统。14. 结核分枝杆菌无细胞提取物中的脂肪酸合成。
Arch Biochem Biophys. 1963 Jan;100:56-65. doi: 10.1016/0003-9861(63)90034-1.
6
The biosynthesis of lignoceric, cerebronic, and nervonic acids.二十四烷酸、脑硫酸和神经酸的生物合成。
J Biol Chem. 1961 Sep;236:2416-20.
7
Column chromatographic purification of octanoyl-CoA.辛酰辅酶A的柱色谱纯化
Anal Biochem. 1967 May;19(2):294-9. doi: 10.1016/0003-2697(67)90165-0.
8
Fatty acid synthesis in mitochondria. Elongation of short-chain fatty acids and formation of unsaturated long-chain fatty acids.
Biochim Biophys Acta. 1968 Jan 10;152(1):50-62. doi: 10.1016/0005-2760(68)90007-6.
9
The mitochondrial fatty acid synthesizing system: general properties and acetate incorporation into monoenoic acids.线粒体脂肪酸合成系统：一般特性及乙酸盐掺入单烯酸的过程
Biochim Biophys Acta. 1966 Jun 1;116(3):425-40. doi: 10.1016/0005-2760(66)90113-5.
10
Direct incorporation of octanoate into long-chain fatty acids by soluble enzymes of Mycobacterium tuberculosis.结核分枝杆菌可溶性酶将辛酸直接掺入长链脂肪酸中。
Biochim Biophys Acta. 1965 Jun 1;98(3):476-85. doi: 10.1016/0005-2760(65)90144-x.

结核分枝杆菌中脂肪酸的延长

Elongation of fatty acids in Mycobacterium tuberculosis.

作者信息

Wang L, Kusaka T, Goldman D S

出版信息

J Bacteriol. 1970 Mar;101(3):781-5. doi: 10.1128/jb.101.3.781-785.1970.

DOI:10.1128/jb.101.3.781-785.1970
PMID:4392396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250391/
Abstract

Cell-free extracts of the H37Ra strain of Mycobacterium tuberculosis contain a soluble enzyme system which catalyzes an elongation reaction of long-chain fatty acids. The predominant reaction involves the addition of a single C(2) unit to the acceptor fatty acid; the elongation takes place exclusively at the carboxyl end of the acceptor molecule. The endogenous acceptor lipid can be removed by solvent extraction of the enzyme system. The lipid-depleted enzyme can be fully reactivated with external acyl coenzyme A, after which elongation with acetyl coenzyme A takes place. The elongation reaction is avidin-insensitive and does not require adenosine triphosphate. Reduced nicotinamide adenine dinucleotide is the source of reducing equivalent, whereas reduced nicotinamide adenine dinucleotide phosphate is without effect.

摘要

结核分枝杆菌H37Ra菌株的无细胞提取物含有一种可溶性酶系统，该系统催化长链脂肪酸的延伸反应。主要反应涉及向受体脂肪酸添加单个C(2)单元；延伸仅在受体分子的羧基末端发生。内源性受体脂质可通过对酶系统进行溶剂萃取去除。脂质耗尽的酶可用外部酰基辅酶A完全重新激活，之后会发生与乙酰辅酶A的延伸反应。延伸反应对抗生物素蛋白不敏感，且不需要三磷酸腺苷。还原型烟酰胺腺嘌呤二核苷酸是还原当量的来源，而还原型烟酰胺腺嘌呤二核苷酸磷酸则无作用。