两名自身免疫性疾病和淋巴网状肿瘤患者的克隆进化。
Clonal evolution in two patients with autoimmune disease and lymphoreticular neoplasia.
作者信息
Adam M, Thorburn M J, Gibbs W N, Brooks S E, Hanchard B
出版信息
Br J Cancer. 1970 Jun;24(2):266-76. doi: 10.1038/bjc.1970.30.
Abstract
Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions.
摘要
本文描述了两个病例，一例确诊为淋巴肉瘤，伴有可疑的自身免疫性疾病；另一例情况相反，循环异常单核细胞表现出对PHA的反应性及异常的染色体构成（克隆进化）。结合先前关于淋巴网状细胞瘤和自身免疫性疾病的细胞遗传学研究以及这两种疾病之间的关系，对这些发现进行了讨论。
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