Schwartz R S, Beldotti L
Science. 1965 Sep 24;149(3691):1511-4. doi: 10.1126/science.149.3691.1511.
The graft versus host reaction which occurs in F(1) hybrid mice injected with parental spleen cells was used to examine several immunological theories of neoplasia. Long-term survivors of this reaction developed lymphoid neoplasms which resembled Hodgkin's disease and lymphosarcoma. Mice with these tumors were chimeras, but the parental cells present within their spleens had specific immunological tolerance toward host antigens. This, together with the finding that the tumors were transplantable only to isogenic recipients, indicates that the tumors were of host rather than donor origin.
将亲代脾细胞注射到F(1) 代杂种小鼠体内所引发的移植物抗宿主反应，被用于检验几种肿瘤形成的免疫学理论。这种反应的长期存活者会发展出类似霍奇金病和淋巴肉瘤的淋巴肿瘤。患有这些肿瘤的小鼠是嵌合体，但它们脾脏内的亲代细胞对宿主抗原具有特异性免疫耐受性。这一点，连同肿瘤仅可移植到同基因受体的发现，表明这些肿瘤起源于宿主而非供体。
