Koeda T, Shibata U, Asaoka H, Yamaki Y, Izawa M
Jpn J Antibiot. 1979 Feb;32(2):180-90.
The pharmacological effects of fosfomycin sodium, a new antibiotic agent, were studied on central nervous system, neuromuscular junction, isolated smooth muscles, blood coagulation, red blood cell resistance, body temperature, permeability of skin vessels and IgG and IgE antibody formation in laboratory animals. Fosfomycin sodium inhibited activities on the isolated smooth muscles, elevated body temperature, and increased permeability of skin vessels. Any of these actions, however, was noticeable only when it was administered in higher doses. Except for these above effects, fosfomycin sodium did not show any actions. Consequently, it can be concluded that fosfomycin sodium has no specific pharmacological actions.
对新型抗生素磷霉素钠在实验动物的中枢神经系统、神经肌肉接头、离体平滑肌、血液凝固、红细胞抵抗力、体温、皮肤血管通透性以及IgG和IgE抗体形成方面的药理作用进行了研究。磷霉素钠抑制离体平滑肌的活动，使体温升高，并增加皮肤血管的通透性。然而，这些作用只有在高剂量给药时才明显。除上述作用外，磷霉素钠未表现出任何其他作用。因此，可以得出结论，磷霉素钠没有特异性药理作用。
