Hashimoto T, Ichikawa S, Kojima T
Jpn J Antibiot. 1977 Jun;30(6):362-85.
The general pharmacological actions of KW-1062 were investigated in order to estimate the effects on the host animals. KW-1062 showed little or no effect on the central nervous system, cardiovascular system, smooth muscle, skeletal muscle, hemolysis, blood coagulation, dermal tissue permeability and antigenicity tests at high doses. KW-1062 showed urinative effect and ototoxicity. But ototoxicity of KW-1062 was less potent than that of gentamicin. KW-1062 has been proved to have a safety margin wider than that of other aminoglycoside antibiotics.
为评估对宿主动物的影响，对KW - 1062的一般药理作用进行了研究。KW - 1062在高剂量时对中枢神经系统、心血管系统、平滑肌、骨骼肌、溶血、血液凝固、皮肤组织通透性和抗原性试验几乎没有影响或无影响。KW - 1062具有利尿作用和耳毒性。但KW - 1062的耳毒性比庆大霉素弱。已证明KW - 1062的安全范围比其他氨基糖苷类抗生素更广。
