[The general pharmacological actions of KW-1062, a new aminoglycoside antibiotic (author's transl)].

The general pharmacological actions of KW-1062 were investigated in order to estimate the effects on the host animals. KW-1062 showed little or no effect on the central nervous system, cardiovascular system, smooth muscle, skeletal muscle, hemolysis, blood coagulation, dermal tissue permeability and antigenicity tests at high doses. KW-1062 showed urinative effect and ototoxicity. But ototoxicity of KW-1062 was less potent than that of gentamicin. KW-1062 has been proved to have a safety margin wider than that of other aminoglycoside antibiotics.