Shimada K, Inamatsu T, Sato K
Jpn J Antibiot. 1979 Feb;32(2):191-4.
The antimicrobial activity of 24 Bacteroides fragilis, 13 Bacteroides thetaiotaomicron and 5 Bacteroides vulgatus, all of which were recent clinical isolates, was determined by the agar dilution technique. These three species had similar susceptibility patterns, but the B. thetaiotaomicron strains were generally less susceptible than the B. fragilis strains. Clindamycin was very active against 81% of the Bacteroides strains at 3.1 mcg/ml of less while 21% of the Bacteroides strains had MICs of 100 mcg/ml or above. Metronidazole was active against all Bacteroides strains at 1.6 mcg/ml or less. The patients with decubitus ulcers and B. fragilis septicemia, who responded satisfactorily to the combination of metronidazole and tobramycin, were presented.
采用琼脂稀释法测定了24株脆弱拟杆菌、13株多形拟杆菌和5株普通拟杆菌的抗菌活性，所有菌株均为近期临床分离株。这三种菌具有相似的药敏模式，但多形拟杆菌菌株通常比脆弱拟杆菌菌株更不易感。克林霉素对81%的拟杆菌菌株在3.1微克/毫升及以下时非常有效，而21%的拟杆菌菌株的最低抑菌浓度为100微克/毫升或更高。甲硝唑对所有拟杆菌菌株在1.6微克/毫升及以下时均有活性。还介绍了褥疮溃疡合并脆弱拟杆菌败血症患者，这些患者对甲硝唑和妥布霉素联合治疗反应良好。
