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猫直肠及内括约肌和外括约肌肾上腺素能受体的体内研究。

A study in vivo of adrenergic receptors in the rectum and in the internal and sphincter of the cat.

作者信息

Kerremans R, Penninckx F

出版信息

Gut. 1970 Aug;11(8):709-14. doi: 10.1136/gut.11.8.709.

DOI:10.1136/gut.11.8.709
PMID:4394290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553097/
Abstract

THE SMOOTH MUSCLE SPHINCTERIC ACTIVITY OF THE ANUS IN CATS IS BASED ON TWO DISTINCT MECHANISMS

a typical anal component, characterized by anal slow pressure waves not related to spike potentials in the internal anal sphincter, and an intestinal-like pressure component related to spiking activity in the internal sphincter. Anal slow pressure waves are influenced by the activity of alpha excitatory receptors within the internal sphincter, whereas no conclusive data are available concerning the action of adrenergic beta receptors on this pressure component. Intestinal-like pressure waves and the correlated spiking activity in the internal anal sphincter are influenced by alpha and beta inhibitory adrenergic receptors. The rectal wall of the cat contains alpha and beta adrenergic receptors producing relaxation.

摘要

猫肛门平滑肌的括约肌活动基于两种不同机制

一种是典型的肛门成分，其特征是肛门缓慢压力波，与肛门内括约肌的锋电位无关；另一种是类似肠道的压力成分，与内括约肌的峰电位活动有关。肛门缓慢压力波受内括约肌内α兴奋性受体活动的影响，而关于肾上腺素能β受体对该压力成分的作用尚无确凿数据。类似肠道的压力波以及肛门内括约肌的相关峰电位活动受α和β抑制性肾上腺素能受体的影响。猫的直肠壁含有产生舒张作用的α和β肾上腺素能受体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c86/1553097/cafa73415c18/gut00686-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c86/1553097/506107a067c4/gut00686-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c86/1553097/cafa73415c18/gut00686-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c86/1553097/506107a067c4/gut00686-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c86/1553097/cafa73415c18/gut00686-0087-a.jpg

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本文引用的文献

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Studies in vivo of the ileocaeco-colic sphincter in the cat and dog.猫和狗回盲结肠括约肌的体内研究。
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A PRELIMINARY INVESTIGATION OF THE PHARMACOLOGY OF THE HUMAN ISOLATED TAENIA COLI PREPARATION.人体离体结肠带制备的药理学初步研究。
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The internal anal sphincter response: manometric studies on its normal physiology, neural pathways, and alteration in bowel disorders.肛门内括约肌反应：关于其正常生理学、神经通路及肠道疾病中改变的测压研究。
J Clin Invest. 1963 Feb;42(2):196-207. doi: 10.1172/JCI104706.
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The cardiac sphincter in the cat.猫的贲门括约肌。
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7
The innervation of the cardia and lower oesophagus in man.人类贲门和食管下段的神经支配。
Br J Surg. 1960 Mar;47:466-72. doi: 10.1002/bjs.18004720503.
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Andrenergic receptive mechanism of canine ileum.犬回肠的肾上腺素能受体机制。
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Catecholamines.儿茶酚胺
Proc R Soc Med. 1967 Mar;60(3):217. doi: 10.1177/003591576706000307.
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Pharmacological characterization of adrenergic receptors.肾上腺素能受体的药理学特性
Pharmacol Rev. 1966 Mar;18(1):503-12.