异丙肾上腺素对人隐静脉肾上腺素能受体的作用。
The effect of isoprenaline on adrenoceptors in human saphenous vein.
作者信息
Coupar I M
出版信息
Br J Pharmacol. 1970 Jul;39(3):465-75. doi: 10.1111/j.1476-5381.1970.tb10355.x.
Abstract
- The order of potency of sympathomimetic amines in causing contraction of strips of human saphenous vein was (-)-adrenaline>(-)-noradrenaline>(-)-phenylephrine>(+/-)-isoprenaline.2. The competitive alpha-adrenoceptor blocking drugs tolazoline, phentolamine, and thymoxamine and the irreversible blocking drug phenoxybenzamine all blocked noradrenaline and isoprenaline contractions.3. Contractions produced by 5-hydroxytryptamine were also blocked by phentolamine and thymoxamine. Fenfluramine-induced contractions were not blocked by thymoxamine or phenoxybenzamine.4. ED50 contracting doses of isoprenaline did not cause consistent relaxation of noradrenaline-contracted strips.5. It is concluded that human saphenous vein contains a dominant population of alpha-adrenoceptors which can be stimulated by high doses of isoprenaline, but the occurrence of beta-adrenoceptors mediating relaxation is rare.
摘要
拟交感胺引起人隐静脉条收缩的效价顺序为（-）-肾上腺素＞（-）-去甲肾上腺素＞（-）-去氧肾上腺素＞（±）-异丙肾上腺素。
竞争性α-肾上腺素能受体阻断药妥拉唑啉、酚妥拉明和百里胺以及不可逆性阻断药酚苄明均能阻断去甲肾上腺素和异丙肾上腺素引起的收缩。
5-羟色胺引起的收缩也被酚妥拉明和百里胺阻断。芬氟拉明引起的收缩不被百里胺或酚苄明阻断。
异丙肾上腺素的ED50收缩剂量并未引起去甲肾上腺素预收缩条的一致性舒张。
得出结论，人隐静脉含有占主导地位的α-肾上腺素能受体群体，高剂量异丙肾上腺素可刺激该受体，但介导舒张的β-肾上腺素能受体很少见。
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