Freedman B J, Hill G B
Thorax. 1971 Jan;26(1):46-50. doi: 10.1136/thx.26.1.46.
The durations of action and side effects of four different pressurized bronchodilator aerosols were compared. One of the preparations contained isoprenaline alone, which was given in a dose of 400 μg. The doses of the three other preparations were adjusted to yield nearly the same peak bronchodilator response as was obtained from 400 μg isoprenaline. These doses differed from those yielded by a single discharge of the standard commercial product. The duration of action of orciprenaline was greater than those of the other preparations. There were no cardiovascular side effects from any of the four preparations. An attempt has been made to establish the principle that drugs whose primary action is similar should be given in equipotential doses when comparing duration of action and side effects.
比较了四种不同的加压支气管扩张气雾剂的作用持续时间和副作用。其中一种制剂仅含异丙肾上腺素，剂量为400μg。调整其他三种制剂的剂量，使其产生的支气管扩张峰值反应与400μg异丙肾上腺素产生的反应几乎相同。这些剂量与标准商业产品单次喷出的剂量不同。奥西那林的作用持续时间比其他制剂更长。这四种制剂均未产生心血管副作用。已尝试确立这样一个原则：在比较作用持续时间和副作用时，主要作用相似的药物应以等效应剂量给药。
