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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Br J Pharmacol. 1971 Jan;41(1):105-12. doi: 10.1111/j.1476-5381.1971.tb09940.x.

In addition to reducing the sensitivity of the end-plate to transmitter, procaine produced changes in the time course of the end-plate potential. The time to peak potential was reduced by procaine, whether recording from fibres paralysed by tubocurarine or from fibres paralysed by high magnesium concentration. The rate of decay of potential was also markedly reduced. Similar observations were made recording spontaneous miniature end-plate potentials.2. Procaine did not produce any marked change in the electrical constants of muscle fibres.3. In the presence of procaine the accumulation of charge at the end-plate was prolonged; the rate of decay of charge was reduced. It is suggested that the prolonged end-plate potentials arise from a prolongation of the end-plate current.

除降低终板对递质的敏感性外，普鲁卡因还使终板电位的时程发生改变。无论从被筒箭毒麻痹的纤维还是从被高镁浓度麻痹的纤维记录，普鲁卡因都能使达到电位峰值的时间缩短。电位的衰减速率也显著降低。记录自发的微小终板电位时也得到了类似的观察结果。2. 普鲁卡因未使肌纤维的电常数发生任何显著变化。3. 在有普鲁卡因存在时，终板处电荷的积累时间延长；电荷的衰减速率降低。有人提出，延长的终板电位是由终板电流的延长引起的。

Br J Pharmacol. 1971 Jan;41(1):105-12. doi: 10.1111/j.1476-5381.1971.tb09940.x.

In addition to reducing the sensitivity of the end-plate to transmitter, procaine produced changes in the time course of the end-plate potential. The time to peak potential was reduced by procaine, whether recording from fibres paralysed by tubocurarine or from fibres paralysed by high magnesium concentration. The rate of decay of potential was also markedly reduced. Similar observations were made recording spontaneous miniature end-plate potentials.2. Procaine did not produce any marked change in the electrical constants of muscle fibres.3. In the presence of procaine the accumulation of charge at the end-plate was prolonged; the rate of decay of charge was reduced. It is suggested that the prolonged end-plate potentials arise from a prolongation of the end-plate current.

除降低终板对递质的敏感性外，普鲁卡因还使终板电位的时程发生改变。无论从被筒箭毒麻痹的纤维还是从被高镁浓度麻痹的纤维记录，普鲁卡因都能使达到电位峰值的时间缩短。电位的衰减速率也显著降低。记录自发的微小终板电位时也得到了类似的观察结果。2. 普鲁卡因未使肌纤维的电常数发生任何显著变化。3. 在有普鲁卡因存在时，终板处电荷的积累时间延长；电荷的衰减速率降低。有人提出，延长的终板电位是由终板电流的延长引起的。