在细胞水平上对3型肺炎球菌多糖抗体反应的特征分析。I. 剂量反应研究以及先前免疫对抗体反应强度的影响。
Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response.
作者信息
Baker P J, Stashak P W, Amsbaugh D F, Prescott B
出版信息
Immunology. 1971 Apr;20(4):469-80.
Abstract
The cytokinetics of the antibody to Type III pneumococcal polysaccharide (SSS-III) were characterized by an immuno-plaque procedure using erythrocytes sensitized with SSS-III. Prior immunization, irrespective of the doses employed, did not result in the development of immunological memory; instead, low-dose paralysis was produced in mice previously immunized with all doses of SSS-III. Dose-response studies revealed that within a given dose range, there was a direct relationship between the immunizing dose and the magnitude of the antibody response obtained. The dose-response curve for SSS-III showed a single optimal dose for immunization; doses only slightly in excess of the optimal dose produced a significant reduction in the magnitude of the antibody response. The implications of these findings, with respect to the development of paralysis to SSS-III, are discussed.
摘要
采用经III型肺炎球菌多糖（SSS-III）致敏的红细胞，通过免疫斑程序对III型肺炎球菌多糖抗体（SSS-III）的细胞动力学进行了表征。预先免疫，无论使用何种剂量，均未导致免疫记忆的形成；相反，先前用所有剂量的SSS-III免疫的小鼠产生了低剂量麻痹。剂量反应研究表明，在给定剂量范围内，免疫剂量与获得的抗体反应强度之间存在直接关系。SSS-III的剂量反应曲线显示出单一的最佳免疫剂量；仅略高于最佳剂量的剂量会导致抗体反应强度显著降低。讨论了这些发现对于SSS-III麻痹发生的意义。
相似文献
1
2
3
4
Immunological paralysis of mice with pneumococcal polysaccharide antigens.用肺炎球菌多糖抗原使小鼠发生免疫麻痹。
Bacteriol Rev. 1971 Sep;35(3):267-89. doi: 10.1128/br.35.3.267-289.1971.
5
6
7
Conversion of type III pneumococcal polysaccharide low responders to high responders by immunization with a thymus-dependent form of antigen.通过用胸腺依赖性抗原形式进行免疫，将III型肺炎球菌多糖低反应者转变为高反应者。
Cell Immunol. 1974 Apr;12(1):49-60. doi: 10.1016/0008-8749(74)90055-0.
8
Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide.免疫麻痹的研究。十一。左聚糖和3型肺炎球菌多糖体外耐受性的比较。
Eur J Immunol. 1973 Aug;3(8):496-502. doi: 10.1002/eji.1830030809.
9
10
引用本文的文献
1
Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem.感染流感的新生猴和成年猴对血凝素茎部表现出强烈的初次抗体反应。
JCI Insight. 2020 Mar 12;5(5):135449. doi: 10.1172/jci.insight.135449.
2
The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain.荚膜多糖的体内抗荚膜多糖反应的性质受细菌荚膜下域的组成和/或结构的显著影响。
J Immunol. 2012 Jan 15;188(2):569-77. doi: 10.4049/jimmunol.1101446. Epub 2011 Dec 7.
3
T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens.抗体对“2型非T淋巴细胞依赖性”抗原反应的T淋巴细胞依赖性
Immunology. 2004 Jan;111(1):1-7. doi: 10.1111/j.1365-2567.2004.01775.x.
4
Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens.CpG 寡脱氧核苷酸对非依赖T细胞2型抗原应答的佐剂效应。
Immunology. 2001 Jan;102(1):67-76. doi: 10.1046/j.1365-2567.2001.01158.x.
5
Molecular structures that influence the immunomodulatory properties of the lipid A and inner core region oligosaccharides of bacterial lipopolysaccharides.影响细菌脂多糖的脂质A和内核区域寡糖免疫调节特性的分子结构。
Infect Immun. 1994 Jun;62(6):2257-69. doi: 10.1128/iai.62.6.2257-2269.1994.
6
The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.骨髓：血清免疫球蛋白的主要来源，但仍是一个被忽视的抗体形成部位。
Clin Exp Immunol. 1981 Oct;46(1):1-8.
7
8
Influence of carrier-specific, thymus-derived cells on the immunologlobulin M antibody response to staphylococcal lipoteichoic acid.载体特异性胸腺来源细胞对针对葡萄球菌脂磷壁酸的免疫球蛋白M抗体反应的影响。
Infect Immun. 1980 Jul;29(1):132-9. doi: 10.1128/iai.29.1.132-139.1980.
9
Immunoglobulin M and G antibody responses and persistence of these antibodies in adults after vaccination with a combined meningococcal group A and group C polysaccharide vaccine.成人接种A群和C群脑膜炎球菌结合多糖疫苗后免疫球蛋白M和G抗体反应及这些抗体的持久性。
Infect Immun. 1982 Aug;37(2):579-85. doi: 10.1128/iai.37.2.579-585.1982.
10
Comparison of the induction of immunoglobulin M and G antibodies in mice with purified pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates.用纯化的3型肺炎球菌多糖、C群脑膜炎球菌多糖及其蛋白结合物诱导小鼠产生免疫球蛋白M和G抗体的比较。
Infect Immun. 1982 Jul;37(1):15-22. doi: 10.1128/iai.37.1.15-22.1982.
本文引用的文献
1
The Precipitation of Bacterial Polysaccharides with Calcium Phosphate : Pneumococcus.磷酸钙对细菌多糖的沉淀作用：肺炎球菌
J Bacteriol. 1935 Feb;29(2):149-61. doi: 10.1128/jb.29.2.149-161.1935.
2
THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. II. THE PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO MULTIPLE INJECTIONS OF ANTIGEN BEGUN AT BIRTH.大鼠对绵羊红细胞产生耐受性的机制。II. 对出生时开始多次注射抗原的空斑形成细胞及抗体反应
J Exp Med. 1965 May 1;121(5):683-95. doi: 10.1084/jem.121.5.683.
3
THE PNEUMOCOCCAL POLYSACCHARIDES.肺炎球菌多糖
Adv Carbohydr Chem. 1964;19:303-58. doi: 10.1016/s0096-5332(08)60285-4.
4
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.脊髓灰质炎病毒中和抗体的形成与特性。II. 19S和7S抗体的形成：持续合成、回忆反应及对X射线照射敏感性方面抗原剂量需求的差异
J Exp Med. 1964 Jan 1;119(1):21-39. doi: 10.1084/jem.119.1.21.
5
Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174.抗体形成。IV. 针对噬菌体φ-X 174的快速和慢速沉降抗体的形成及免疫记忆
J Exp Med. 1963 Mar 1;117(3):457-77. doi: 10.1084/jem.117.3.457.
6
Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.肺炎球菌多糖诱导小鼠免疫麻痹机制的研究。
J Immunol. 1955 Jan;74(1):17-26.
7
Quantitative studies of the adoptive immunological memory in mice. II. Linear transmission of cellular memory.小鼠过继免疫记忆的定量研究。II. 细胞记忆的线性传递。
J Exp Med. 1967 Feb 1;125(2):199-211. doi: 10.1084/jem.125.2.199.
8
9
Antigens in immunity. VII. Analysis of immunological memory.免疫中的抗原。VII. 免疫记忆分析。
Immunology. 1965 Oct;9(4):333-48.
10
The effect of antigen dosage on the response of adoptively transferred cells.抗原剂量对过继转移细胞反应的影响。
Immunology. 1965 Jun;8(6):549-56.
Zotero 插件