Turss R, Retzlaff K, Hebrock R
Klin Monbl Augenheilkd. 1979 Feb;174(2):177-87.
Report on the treatment of 41 patients in the last 10 years. In chronic corneal diseases epikeratoprosthesis is possible when every other therapy failed. With growing experience functional results are better and complications seldom. Since several years we use glued-on contact lenses in acute ulcers too in order to avoid emergency keratoplasty. When suitable donor material is missing or if plastic surgery of the eye lids is necessary the artificial epithelium prevents ulcer perforation as a mechanical collagenase inhibitor. The anterior chamber can be reinstalled in perforated ulcers by sealing with cyanoacrylate glue and covering with artificial epithelium. A corticosteroid therapy of the iritis becomes possible to avoid the frequent complication of anterior synechia in later keratoplasty. By reducing the steroid dosis vascularisation of the ulcer is reached and a corneal grafting can be evaded sometimes if the prognosis of keratoplasty is poor or the central cornea is clear such as in ulcers near the limbus.
过去10年41例患者的治疗报告。在慢性角膜疾病中，当其他所有治疗方法均失败时，可采用角膜表面镜片术。随着经验的积累，功能效果更佳，并发症也很少见。数年来，我们也在急性溃疡中使用粘贴式隐形眼镜以避免急诊角膜移植术。当缺乏合适的供体材料或需要进行眼睑整形手术时，人工上皮作为一种机械性胶原酶抑制剂可防止溃疡穿孔。对于穿孔性溃疡，可通过用氰基丙烯酸酯胶密封并覆盖人工上皮来重建前房。虹膜睫状体炎的皮质类固醇治疗有助于避免后期角膜移植术中常见的前粘连并发症。通过减少类固醇剂量，可实现溃疡的血管化，并且如果角膜移植术预后不佳或中央角膜清晰（如角膜缘附近的溃疡），有时可以避免角膜移植。
