实验性高血压大鼠的心血管反应性
Cardiovascular reactivity in the experimental hypertensive rat.
作者信息
Finch L
出版信息
Br J Pharmacol. 1971 May;42(1):56-65. doi: 10.1111/j.1476-5381.1971.tb07086.x.
Abstract
- In pithed preparations, deoxycorticosterone (DOCA)/NaCl-induced hypertensive rats showed increased cardiovascular reactivity to injected noradrenaline, DMPP, tyramine, angiotensin and to sympathetic nerve stimulation.2. Pithed, chronic renal hypertensive rats showed similar hyperreactivity to noradrenaline, DMPP and tyramine but responses to sympathetic nerve stimulation were within normal limits.3. In the isolated, Krebs perfused mesentery preparation, vessels obtained from both DOCA/NaCl and renal hypertensive rats showed hyperreactivity to injected noradrenaline. Responses to periarterial nerve stimulation were also markedly increased in preparations from DOCA/NaCl hypertensive rats, while preparations from renal hypertensive rats showed this effect only at higher rates of stimulation (12 and 25 Hz).
摘要
在脊髓横断制备中，脱氧皮质酮（DOCA）/氯化钠诱导的高血压大鼠对注射去甲肾上腺素、二甲基苯基哌嗪（DMPP）、酪胺、血管紧张素以及交感神经刺激的心血管反应性增强。
脊髓横断的慢性肾性高血压大鼠对去甲肾上腺素、DMPP和酪胺表现出类似的高反应性，但对交感神经刺激的反应在正常范围内。
在离体的、用Krebs液灌注的肠系膜制备中，来自DOCA/氯化钠和肾性高血压大鼠的血管对注射去甲肾上腺素均表现出高反应性。在DOCA/氯化钠高血压大鼠的制备中，对动脉周围神经刺激的反应也明显增强，而肾性高血压大鼠的制备仅在较高刺激频率（12和25赫兹）时表现出这种效应。
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