实验性高血压大鼠的心血管反应性
Cardiovascular reactivity in the experimental hypertensive rat.
作者信息
Finch L
出版信息
Br J Pharmacol. 1971 May;42(1):56-65. doi: 10.1111/j.1476-5381.1971.tb07086.x.
Abstract
- In pithed preparations, deoxycorticosterone (DOCA)/NaCl-induced hypertensive rats showed increased cardiovascular reactivity to injected noradrenaline, DMPP, tyramine, angiotensin and to sympathetic nerve stimulation.2. Pithed, chronic renal hypertensive rats showed similar hyperreactivity to noradrenaline, DMPP and tyramine but responses to sympathetic nerve stimulation were within normal limits.3. In the isolated, Krebs perfused mesentery preparation, vessels obtained from both DOCA/NaCl and renal hypertensive rats showed hyperreactivity to injected noradrenaline. Responses to periarterial nerve stimulation were also markedly increased in preparations from DOCA/NaCl hypertensive rats, while preparations from renal hypertensive rats showed this effect only at higher rates of stimulation (12 and 25 Hz).
摘要
在脊髓横断制备中，脱氧皮质酮（DOCA）/氯化钠诱导的高血压大鼠对注射去甲肾上腺素、二甲基苯基哌嗪（DMPP）、酪胺、血管紧张素以及交感神经刺激的心血管反应性增强。
脊髓横断的慢性肾性高血压大鼠对去甲肾上腺素、DMPP和酪胺表现出类似的高反应性，但对交感神经刺激的反应在正常范围内。
在离体的、用Krebs液灌注的肠系膜制备中，来自DOCA/氯化钠和肾性高血压大鼠的血管对注射去甲肾上腺素均表现出高反应性。在DOCA/氯化钠高血压大鼠的制备中，对动脉周围神经刺激的反应也明显增强，而肾性高血压大鼠的制备仅在较高刺激频率（12和25赫兹）时表现出这种效应。
相似文献
1
Cardiovascular reactivity in the experimental hypertensive rat.实验性高血压大鼠的心血管反应性
Br J Pharmacol. 1971 May;42(1):56-65. doi: 10.1111/j.1476-5381.1971.tb07086.x.
2
Cardiovascular reactivity in renal and spontaneously hypertensive rats.肾性高血压大鼠和自发性高血压大鼠的心血管反应性
Arch Int Pharmacodyn Ther. 1978 Jul;234(1):49-57.
3
Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension.从常用的高血压大鼠模型中获取的肠系膜血管床，在外周动脉神经刺激或外源性去甲肾上腺素输注时的反应存在差异。
Clin Exp Pharmacol Physiol. 2019 May;46(5):427-434. doi: 10.1111/1440-1681.13068. Epub 2019 Feb 25.
4
Responses of mean arterial pressure to pressor agents and diuretics in renal hypertensive and salt hypertensive rats.肾性高血压大鼠和盐性高血压大鼠平均动脉压对升压药和利尿剂的反应。
Br J Pharmacol. 1971 Jun;42(2):179-92. doi: 10.1111/j.1476-5381.1971.tb07099.x.
5
Augmented sympathetic nerve activity and pressor responsiveness in DOCA hypertensive rats.去氧皮质酮高血压大鼠交感神经活动增强及升压反应性增强
Hypertension. 1980 Jan-Feb;2(1):97-101. doi: 10.1161/01.hyp.2.1.97.
6
A comparison of the effects of chemical sympathectomy by 6-hydroxydopamine in newborn and adult rats.6-羟基多巴胺对新生大鼠和成年大鼠进行化学性交感神经切除术的效果比较。
Br J Pharmacol. 1973 Feb;47(2):249-60. doi: 10.1111/j.1476-5381.1973.tb08322.x.
7
Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.肾交感神经在自发性高血压大鼠中调节肾血管对血管紧张素II反应的作用。
J Pharmacol Exp Ther. 2006 Jun;317(3):1330-6. doi: 10.1124/jpet.106.101279. Epub 2006 Mar 14.
8
9
Critical opening pressure and reactivity of tail vessels in conscious hypertensive rats.清醒高血压大鼠尾血管的临界开放压力和反应性
Can J Physiol Pharmacol. 1976 Jun;54(3):314-21. doi: 10.1139/y76-045.
10
Evidence for the involvement of alpha-adrenoceptor blockade in the antihypertensive action of diazoxide in the renal hypertensive rat.α-肾上腺素能受体阻断参与二氮嗪对肾性高血压大鼠降压作用的证据。
Eur J Pharmacol. 1975 Jun-Jul;32(02):273-8. doi: 10.1016/0014-2999(75)90293-9.
引用本文的文献
1
Central adrenergic neurones and the initiation and development of experimental hypertension.中枢肾上腺素能神经元与实验性高血压的发生和发展
Experientia. 1972 Oct 15;28(10):1200-3. doi: 10.1007/BF01946170.
2
Distribution of cardiac output and nutritional blood flow in the unanesthetized rat: alterations during experimental renal hypertension.
Pflugers Arch. 1973 Oct 22;343(3):257-66. doi: 10.1007/BF00586048.
3
Depressor responses to spinal stimulation in the pithed rat.去脑大鼠对脊髓刺激的降压反应。
Br J Pharmacol. 1972 Jun;45(2):218-28. doi: 10.1111/j.1476-5381.1972.tb08077.x.
4
Proceedings: An increased reactivity in hypertensive animals after prolonged antihypertensive therapy.研究结果：长期降压治疗后高血压动物的反应性增强。
Br J Pharmacol. 1974 Nov;52(3):473P.
5
Acidaemia produced by spinal stimulation in the pithed rat.脊髓刺激致去大脑大鼠酸血症。
J Physiol. 1973 Oct;234(1):229-40. doi: 10.1113/jphysiol.1973.sp010343.
6
An increased reactivity in hypertensive rats unaffected by prolonged antihypertensive therapy.长期抗高血压治疗未影响的高血压大鼠反应性增加。
Br J Pharmacol. 1975 Aug;54(4):437-43. doi: 10.1111/j.1476-5381.1975.tb07589.x.
本文引用的文献
1
THE EFFECT OF SYMPATHETIC NERVE STIMULATION OF VASOCONSTRICTOR RESPONSES IN PERFUSED MESENTERIC BLOOD VESSELS OF THE RAT.大鼠肠系膜灌注血管中交感神经刺激对血管收缩反应的影响。
J Physiol. 1965 Mar;177(1):21-30. doi: 10.1113/jphysiol.1965.sp007572.
2
Neurogenic control of peripheral resistance in renal hypertension.
Circ Res. 1963 May;12(5) Pt 2:562-72. doi: 10.1161/01.res.12.5.562.
3
Comparative reactivities of aortic strips from hypertensive and normotensive rats to epinephrine and levarterenol.高血压大鼠和正常血压大鼠主动脉条对肾上腺素和去甲肾上腺素的反应性比较
Circ Res. 1959 Mar;7(2):196-201. doi: 10.1161/01.res.7.2.196.
4
The question of vascular hyper-responsiveness in hypertension.
Circ Res. 1958 Mar;6(2):185-93. doi: 10.1161/01.res.6.2.185.
5
Ionic composition of the aorta in renal and adrenal hypertension.肾性和肾上腺性高血压时主动脉的离子组成
Am J Physiol. 1958 Feb;192(2):325-30. doi: 10.1152/ajplegacy.1958.192.2.325.
6
Studies on vascular reactivity in normotensive and metacorticoid hypertensive rats.正常血压和皮质激素性高血压大鼠的血管反应性研究。
Am Heart J. 1956 Sep;52(3):410-8. doi: 10.1016/0002-8703(56)90215-0.
7
Abnormal storage of norepinephrine in experimental hypertension in the rat.去甲肾上腺素在大鼠实验性高血压中的异常储存。
Circ Res. 1967 Nov;21(5):583-91. doi: 10.1161/01.res.21.5.583.
8
[Differences between tyramine and dimethylphenylpiperazine in the Ca++-dependency and in the temporary course of noradrenaline release from the isolated rabbit heart].[酪胺与二甲基苯基哌嗪在钙离子依赖性以及从离体兔心脏释放去甲肾上腺素的时间过程方面的差异]
Experientia. 1967 Nov 15;23(11):933-4. doi: 10.1007/BF02136230.
9
Turnover and synthesis of norepinephrine in experimental hypertension in rats.大鼠实验性高血压中去甲肾上腺素的周转与合成
Circ Res. 1969 Sep;25(3):285-91. doi: 10.1161/01.res.25.3.285.
10
Synthesis and turnover of norepinephrine in the heart of the spontaneously hypertensive rat.自发性高血压大鼠心脏中去甲肾上腺素的合成与周转
Circ Res. 1969 Jan;24(1):85-91. doi: 10.1161/01.res.24.1.85.
Zotero 插件