肾性高血压大鼠和自发性高血压大鼠的心血管反应性
Cardiovascular reactivity in renal and spontaneously hypertensive rats.
作者信息
Kubo T
出版信息
Arch Int Pharmacodyn Ther. 1978 Jul;234(1):49-57.
Pressor reactivity to noradrenaline or vasopressin was studied in unanaesthetized, pithed and isolated perfused hindquarter, preparations from renal and spontaneously hypertensive rats. Unanaesthetized renal and spontaneously hypertensive rats showed hyperreactivity to noradrenaline and vasopressin. Vascular responses of noradrenaline in pithed and isolated perfused hindquarter preparations were to a lesser extent but significantly greater in the renal hypertensive rat, while responses of pithed and isolated perfused hindquarter preparations to noradrenaline were within normal limits in the spontaneously hypertensive rat.
在未麻醉、脊髓损毁以及离体灌注后肢的肾性高血压大鼠和自发性高血压大鼠制备物中，研究了对去甲肾上腺素或血管加压素的升压反应性。未麻醉的肾性高血压大鼠和自发性高血压大鼠对去甲肾上腺素和血管加压素表现出高反应性。脊髓损毁和离体灌注后肢制备物中去甲肾上腺素的血管反应在肾性高血压大鼠中程度较小但显著增强，而脊髓损毁和离体灌注后肢制备物对去甲肾上腺素的反应在自发性高血压大鼠中处于正常范围内。
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