溴苄铵对离体兔主动脉条对钾和酪胺收缩反应的增强作用。

Bretylium potentiation of the contractor responses of isolated rabbit aortic strips to potassium and tyramine.

作者信息

Kurahashi K, Shibata S

出版信息

Br J Pharmacol. 1971 Sep;43(1):210-21. doi: 10.1111/j.1476-5381.1971.tb07170.x.

DOI:10.1111/j.1476-5381.1971.tb07170.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665950/

Abstract

Pretreatment of rabbit aortic strips with bretylium potentiated the contractor response to potassium and tyramine but not to noradrenaline. On the other hand, such pretreatment inhibited the response to nicotine.2. Even in reserpinized or cold stored aortic strips, pretreatment with bretylium enhanced the contractor response to potassium and tyramine.3. Pretreatment of fresh, reserpinized, or cold stored aortic strips with pheniprazine potentiated the contractor response to potassium and tyramine.4. Pretreatment of aortic strips with bretylium or pheniprazine did not potentiate the response to 5-hydroxytryptamine (5-HT).5. The results indicate that both bretylium and pheniprazine potentiate the action of tyramine and potassium, not by presynaptic mechanisms, but by postsynaptic action, causing an increase in the sensitivity of the effector cells to the stimulants.

摘要

用溴苄铵预处理兔主动脉条可增强其对钾和酪胺的收缩反应，但对去甲肾上腺素无此作用。另一方面，这种预处理可抑制对尼古丁的反应。
即使在利血平化或冷藏的主动脉条中，用溴苄铵预处理也可增强其对钾和酪胺的收缩反应。
用苯苄胺预处理新鲜、利血平化或冷藏的主动脉条可增强其对钾和酪胺的收缩反应。
用溴苄铵或苯苄胺预处理主动脉条对5-羟色胺（5-HT）的反应无增强作用。
结果表明，溴苄铵和苯苄胺增强酪胺和钾的作用，并非通过突触前机制，而是通过突触后作用，导致效应细胞对刺激物的敏感性增加。