Gottrup F, Ornsholt J, Andersen D
Scand J Gastroenterol. 1979;14(7):857-64. doi: 10.3109/00365527909181416.
The effect of beta-adrenoceptor blockade by propranolol and practolol on submaximally pentagastrin-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Propranolol (0.5 mg/kg) intravenously augmented gastric acid output in vagotomized dogs, more after truncal and selective vagotomy than after parietal cell vagotomy. Vagally innervated dogs also showed an increase, but to a lesser degree and not statistically significant. The increase restored the acid output to preoperative levels in the vagotomized dogs. Practolol (1.0 mg/kg) intravenously resulted in a slight and insignificant increase in acid output in dogs with truncal vagotomy and had only a negligible effect in vagally innervated dogs and after selective and parietal cell vagotomy. It is concluded that propranolol augments pentagastrin-stimulated acid output in vagotomized dogs, and this augmentation was most pronounced in the totally vagotomized stomach. Practolol had minor influence on gastric acid secretion. This effect of the two beta-blocking agents indicates that beta 2-blockade is most important for the secretory augmentation. The restoration of postvagotomy acid secretion to preoperative levels suggests that adrenergic influence is important for the decrease in pentagastrin-stimulated acid secretion after vagotomy.
在清醒未切断迷走神经的和已切断迷走神经的胃瘘犬中，研究了普萘洛尔和心得宁对五肽胃泌素次最大刺激胃酸分泌的β-肾上腺素能受体阻断作用。静脉注射普萘洛尔（0.5mg/kg）可增加切断迷走神经犬的胃酸分泌量，在进行迷走神经干切断术和选择性迷走神经切断术后比壁细胞迷走神经切断术后增加得更多。有迷走神经支配的犬也有增加，但程度较小且无统计学意义。这种增加使切断迷走神经犬的胃酸分泌量恢复到术前水平。静脉注射心得宁（1.0mg/kg）可使迷走神经干切断术犬的胃酸分泌量略有增加，但无统计学意义，对有迷走神经支配的犬以及选择性迷走神经切断术和壁细胞迷走神经切断术后的犬只有可忽略不计的影响。得出的结论是，普萘洛尔可增加切断迷走神经犬中五肽胃泌素刺激的胃酸分泌量，且这种增加在完全切断迷走神经的胃中最为明显。心得宁对胃酸分泌的影响较小。这两种β受体阻滞剂的这种作用表明，β2受体阻断对分泌增加最为重要。迷走神经切断术后胃酸分泌恢复到术前水平表明，肾上腺素能影响对迷走神经切断术后五肽胃泌素刺激的胃酸分泌减少很重要。
