Gottrup F, Andersen D, Stødkilde Jørgensen H
Scand J Gastroenterol. 1980;15(5):555-9. doi: 10.3109/00365528009182215.
The effect of beta-adrenoreceptor blockade by propranolol and practolol on basal secretion and on submaximally histamine-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Neither propranolol (0.5 mg/kg) nor practolol (1.0 mg/kg), both intravenously, had a significant influence on basal or histamine-stimulated gastric acid secretion in non-vagotomized and vagotomized dogs. It is concluded that beta-adrenergic blockade has no influence on basal or histamine-stimulated gastric acid secretion in dogs. Furthermore, no differences were found between the non-vagotomized and the vagotomized stomach.
在清醒未切断迷走神经及切断迷走神经的胃瘘犬中，研究了普萘洛尔和普拉洛尔对基础分泌以及组胺亚最大刺激胃酸分泌的β-肾上腺素能受体阻断作用。静脉注射普萘洛尔（0.5mg/kg）和普拉洛尔（1.0mg/kg），对未切断迷走神经和切断迷走神经的犬的基础或组胺刺激的胃酸分泌均无显著影响。结论是β-肾上腺素能阻断对犬的基础或组胺刺激的胃酸分泌无影响。此外，未切断迷走神经的胃和切断迷走神经的胃之间未发现差异。
