兔子中枢体温调节机制中存在β-肾上腺素能受体的证据。
Evidence for the presence of -adrenoceptors in the central thermoregulatory mechanism of rabbits.
作者信息
Dhawan B N, Dua P R
出版信息
Br J Pharmacol. 1971 Nov;43(3):497-503. doi: 10.1111/j.1476-5381.1971.tb07180.x.
Abstract
- The effects of intracerebroventricular administration of some alpha- and beta-adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated.2. Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active.3. The noradrenaline response was blocked by alpha-adrenoceptor blocking agents while beta-adrenoceptor antagonists had no effect.4. alpha-Methyl-noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline.5. The possible presence of alpha-adrenoceptors in the central thermoregulatory mechanisms is suggested.
摘要
研究了脑室内注射某些α-和β-肾上腺素能受体激动剂及拮抗剂对家兔体温的影响。
去甲肾上腺素使体温呈剂量依赖性升高。其他儿茶酚胺的活性较低。
α-肾上腺素能受体阻断剂可阻断去甲肾上腺素的反应，而β-肾上腺素能受体拮抗剂则无作用。
α-甲基去甲肾上腺素和间羟胺有一定的升温作用，但显著降低了去甲肾上腺素的反应。
提示中枢体温调节机制中可能存在α-肾上腺素能受体。
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