儿茶酚胺对鸽子体温调节的影响。
Effects of catecholamines on thermoregulation in pigeons.
作者信息
Chawla N, Johri M B, Saxena P N, Singhal K C
出版信息
Br J Pharmacol. 1974 Aug;51(4):497-501. doi: 10.1111/j.1476-5381.1974.tb09667.x.
1 In unanaesthetized pigeons, kept at room temperature (20-23 degrees C) the effects on cloacal temperature were examined of catecholamines, phenoxybenzamine and propranolol, injected into the cerebral ventricles.2 Noradrenaline, adrenaline, dopamine and isoprenaline caused a fall in cloacal temperature.3 Phenoxybenzamine produced a long-lasting small rise in cloacal temperature. This rise is attributed to removal of the hypothermic effect of noradrenaline released continuously from adrenergic neurones ending in the anterior hypothalamus. Propranolol produced a slight fall in cloacal temperature.4 The hypothermic effects of noradrenaline, adrenaline and dopamine were prevented by phenoxybenzamine but not by propranolol. They are therefore attributed to activation of alpha-adrenoceptors.5 The hypothermic effect of isoprenaline was not prevented by either phenoxybenzamine or propranolol. The effect can therefore not be attributed to activation of either alpha or beta-adrenoceptors. Propranolol actually accentuated the isoprenaline-induced hypothermia.
在室温（20 - 23摄氏度）下未麻醉的鸽子中，研究了向脑室注射儿茶酚胺、酚苄明和普萘洛尔对泄殖腔温度的影响。
去甲肾上腺素、肾上腺素、多巴胺和异丙肾上腺素导致泄殖腔温度下降。
酚苄明使泄殖腔温度出现持续的小幅上升。这种上升归因于消除了从前下丘脑终末的肾上腺素能神经元持续释放的去甲肾上腺素的降温作用。普萘洛尔使泄殖腔温度略有下降。
酚苄明可阻止去甲肾上腺素、肾上腺素和多巴胺的降温作用，但普萘洛尔不能。因此，它们的降温作用归因于α - 肾上腺素能受体的激活。
酚苄明和普萘洛尔均不能阻止异丙肾上腺素的降温作用。因此，该作用不能归因于α或β - 肾上腺素能受体的激活。普萘洛尔实际上加剧了异丙肾上腺素诱导的体温过低。
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