对β-肾上腺素能受体兴奋剂的耐药性（哮喘死亡人数增加的一种可能解释）。
Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths).
作者信息
Conolly M E, Davies D S, Dollery C T, George C F
出版信息
Br J Pharmacol. 1971 Oct;43(2):389-402.
Abstract
- Resistance to isoprenaline has been produced in man and dog by prolonged exposure to the same, or the pharmacologically similar compounds, terbutaline and isoetharine.2. In guinea-pigs, pretreatment with these agents increases asthma mortality provoked by histamine which suggests that this resistance may reduce the effectiveness of endogenous sympathetic drive to the bronchi.3. Possible mechanisms by which the asthma death rate could be increased are discussed.4. It is suggested that a drug-induced cross resistance to endogenous sympathetic stimulation could have led to a deterioration of the asthmatic state in patients using the pressurized aerosols of sympathomimetic bronchodilators and that this might account for the rise in asthma death rate.
摘要
- 长期接触异丙肾上腺素、或药理性质相似的化合物特布他林和异丙喘宁，可使人和犬对异丙肾上腺素产生耐药性。2. 在豚鼠中，用这些药物进行预处理会增加组胺诱发的哮喘死亡率，这表明这种耐药性可能会降低内源性交感神经对支气管驱动的有效性。3. 讨论了哮喘死亡率可能增加的潜在机制。4. 有人提出，药物诱导的对内源性交感神经刺激的交叉耐药性，可能导致使用拟交感神经支气管扩张剂压力气雾剂的患者哮喘状态恶化，这可能是哮喘死亡率上升的原因。
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Br J Pharmacol. 1971 Oct;43(2):389-402.
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Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma.哮喘患者血气张力对氨茶碱和异丙肾上腺素的反应。
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Death in asthmatics.哮喘患者的死亡
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Iatrogenic asthma associated with adrenergic aerosols.与肾上腺素能气雾剂相关的医源性哮喘。
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Effect of propranolol on ventilatory function.普萘洛尔对通气功能的影响。
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The metabolic fate of DL(7-3H)isoprenaline in man and dog.DL(7-³H)异丙肾上腺素在人和狗体内的代谢归宿。
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The cardio-toxicity of isoprenaline during hypoxia.缺氧时异丙肾上腺素的心脏毒性。
Br J Pharmacol. 1969 May;36(1):35-45. doi: 10.1111/j.1476-5381.1969.tb08301.x.
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Digital heart rate meter.数字心率计。
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Sudden sniffing death.突然嗅吸致死
JAMA. 1970 Jun 22;212(12):2075-9.
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