利血平对参与肾上腺素合成的肾上腺酶活性的影响。

Effect of reserpine on the activity of adrenal enzymes involved in the synthesis of adrenaline.

Bhagat B, Burke W J, Davis J W

Br J Pharmacol. 1971 Dec;43(4):819-27. doi: 10.1111/j.1476-5381.1971.tb07218.x.

Abstract

After administration of reserpine to rats, the tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) activity in their adrenal glands was found to be increased under in vitro conditions.2. The increase in TH activity occurred at 12-18 h after reserpine whereas the PNMT activity increased at 30 hours. Unlike the TH, the increase in PNMT activity did not appear to be neuronally mediated since ganglion blockade by chlorisondamine failed to antagonize the reserpine-induced increase in PNMT activity. The increase in PNMT activity may be a response to increased utilization of catecholamines.3. Hypophysectomy resulted in a diminution of the activities of both enzymes; the activity of TH, but not of PNMT, could be partially restored by reserpine. ACTH restored the activities of both enzymes almost to normal.4. The differential effect of reserpine suggests that the activities of these two enzymes are controlled by different mechanisms.

摘要

给大鼠注射利血平后，发现其肾上腺中酪氨酸羟化酶（TH）和苯乙醇胺 - N - 甲基转移酶（PNMT）的活性在体外条件下有所增加。
TH活性在利血平注射后12 - 18小时增加，而PNMT活性在30小时增加。与TH不同，PNMT活性的增加似乎不是由神经元介导的，因为氯异吲哚胺对神经节的阻断未能拮抗利血平诱导的PNMT活性增加。PNMT活性的增加可能是对儿茶酚胺利用增加的一种反应。
垂体切除导致两种酶的活性降低；TH的活性，但不是PNMT的活性，可通过利血平部分恢复。促肾上腺皮质激素（ACTH）将两种酶的活性几乎恢复到正常水平。
利血平的不同作用表明这两种酶的活性受不同机制控制。