普萘洛尔、4-羟基普萘洛尔和美多心安对麻醉犬血流动力学影响的比较。
A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogs.
作者信息
Fitzgerald J D, O'Donnell S R
出版信息
Br J Pharmacol. 1972 Jun;45(2):207-17. doi: 10.1111/j.1476-5381.1972.tb08076.x.
Abstract
- The haemodynamic effects of propranolol, practolol and 4-hydroxypropranolol have been compared in anaesthetized dogs both at free heart rates and at heart rates fixed by electrical pacing. All three drugs produced a fall in heart rate at the lowest dose of 0.09 mg/kg.2. Practolol caused less change in dP/dt, cardiac output and blood pressure than did propranolol. 4-Hydroxypropranolol had intermediate effects. Since the changes in dP/dt caused by these three drugs were still present when the heart rate was fixed by pacing, it is concluded that these were independent of changes in heart rate.3. The fact that practolol and 4-hydroxypropranolol cause less change in haemodynamic function than propranolol may be associated with the intrinsic sympathomimetic activity possessed by the first two of these drugs.
摘要
已在麻醉犬中比较了普萘洛尔、普拉洛尔和4-羟基普萘洛尔在自由心率以及电起搏固定心率时的血流动力学效应。所有三种药物在最低剂量0.09mg/kg时均使心率下降。
普拉洛尔引起的dp/dt、心输出量和血压变化比普萘洛尔小。4-羟基普萘洛尔的效应介于两者之间。由于当通过起搏固定心率时，这三种药物引起的dp/dt变化仍然存在，因此得出结论，这些变化与心率变化无关。
普拉洛尔和4-羟基普萘洛尔引起的血流动力学功能变化比普萘洛尔小这一事实，可能与前两种药物所具有的内在拟交感活性有关。
相似文献
1
A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogs.普萘洛尔、4-羟基普萘洛尔和美多心安对麻醉犬血流动力学影响的比较。
Br J Pharmacol. 1972 Jun;45(2):207-17. doi: 10.1111/j.1476-5381.1972.tb08076.x.
2
The haemodynamic effects of ( )-propranolol, dexpropranolol, oxprenolol, practolol and sotalol in anaesthetised dogs.（）-普萘洛尔、右旋普萘洛尔、氧烯洛尔、普拉洛尔和索他洛尔对麻醉犬的血流动力学影响。
Eur J Pharmacol. 1972 Jan;17(1):123-34. doi: 10.1016/0014-2999(72)90278-6.
3
The influence of the intrinsic sympathomimetic activity of beta-adrenoceptor antagonists on haemodynamic effects in anaesthetized dogs.β-肾上腺素能受体拮抗剂的内在拟交感活性对麻醉犬血流动力学效应的影响。
Clin Exp Pharmacol Physiol. 1979 Jan-Feb;6(1):11-9. doi: 10.1111/j.1440-1681.1979.tb00002.x.
4
[Selective beta-blocking action of practolol (ICI 50.172)].[心得安（ICI 50.172）的选择性β受体阻滞作用]
Minerva Anestesiol. 1969 Dec;35(12):1286-94.
5
6
Comparison of immediate haemodynamic effects of three beta-adrenergic blocking agents.三种β-肾上腺素能阻滞剂即时血流动力学效应的比较。
Postgrad Med J. 1970 Nov:Suppl:44-9.
7
8
Haemodynamic effects of oxprenolol and practolol in dogs under halothane anaesthesia.氟烷麻醉下氧烯洛尔和心得宁对犬的血流动力学影响。
Br J Anaesth. 1971 Jan;43(1):25-32. doi: 10.1093/bja/43.1.25.
9
[Comparison of the hemodynamic effects in man of 2 beta-blockaders: propranolol and practolol].[两种β受体阻滞剂（普萘洛尔和醋氨心安）对人体血流动力学影响的比较]
Boll Soc Ital Cardiol. 1972;17(2):91-101.
10
Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol.普萘洛尔的代谢产物4-羟基普萘洛尔的药理学
Br J Pharmacol. 1971 Sep;43(1):222-35. doi: 10.1111/j.1476-5381.1971.tb07171.x.
引用本文的文献
1
Pharmacodynamic properties of beta-adrenergic receptor blocking drugs in man.β-肾上腺素能受体阻断药在人体中的药效学特性。
Drugs. 1974;7(1):8-38. doi: 10.2165/00003495-197407010-00002.
本文引用的文献
1
General anesthesia and circulatory homeostasis.全身麻醉与循环稳态。
Physiol Rev. 1960 Apr;40:187-218. doi: 10.1152/physrev.1960.40.2.187.
2
Effect of propranolol on left ventricular work in aortic stenosis.普萘洛尔对主动脉瓣狭窄时左心室作功的影响。
Br Heart J. 1967 Nov;29(6):871-82. doi: 10.1136/hrt.29.6.871.
3
Hemodynamic changes after beta adrenergic blockade.β肾上腺素能阻滞剂后的血流动力学变化。
Am J Cardiol. 1966 Sep;18(3):317-20. doi: 10.1016/0002-9149(66)90048-8.
4
Effect of beta adrenergic blockade on the cardiovascular dynamics.β肾上腺素能阻滞剂对心血管动力学的影响。
Am J Physiol. 1966 Apr;210(4):833-7. doi: 10.1152/ajplegacy.1966.210.4.833.
5
Haemodynamic effects of I.C.I. 50172 in patients with ischaemic heart disease.ICI 50172对缺血性心脏病患者的血流动力学影响。
Br Med J. 1968 Jan 27;1(5586):215-6. doi: 10.1136/bmj.1.5586.215.
6
A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474.第三类抗心律失常作用。MJ 1999和AH 3474对心房和心室细胞内电位的影响以及对心肌的其他药理作用。
Br J Pharmacol. 1970 Aug;39(4):675-87. doi: 10.1111/j.1476-5381.1970.tb09893.x.
7
The circulatory effects of practolol (ICI 50172) in patients with acute myocardial infarction.心得宁（ICI 50172）对急性心肌梗死患者的循环系统影响
Cardiovasc Res. 1970 Apr;4(2):188-93. doi: 10.1093/cvr/4.2.188.
8
Hemodynamic effects of two beta-adrenergic blocking drugs in anesthetized intact dogs.两种β-肾上腺素能阻断药物对麻醉状态下完整犬的血流动力学影响。
Am Heart J. 1966 Jul;72(1):38-49. doi: 10.1016/0002-8703(66)90626-0.
9
The haemodynamic effects of ( )-propranolol, dexpropranolol, oxprenolol, practolol and sotalol in anaesthetised dogs.（）-普萘洛尔、右旋普萘洛尔、氧烯洛尔、普拉洛尔和索他洛尔对麻醉犬的血流动力学影响。
Eur J Pharmacol. 1972 Jan;17(1):123-34. doi: 10.1016/0014-2999(72)90278-6.
10
Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol.普萘洛尔的代谢产物4-羟基普萘洛尔的药理学
Br J Pharmacol. 1971 Sep;43(1):222-35. doi: 10.1111/j.1476-5381.1971.tb07171.x.
Zotero 插件