Amsbaugh D F, Hansen C T, Prescott B, Stashak P W, Barthold D R, Baker P J
J Exp Med. 1972 Oct 1;136(4):931-49. doi: 10.1084/jem.136.4.931.
The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F(1), F(2), and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.
在由高反应性（BALB/cAnN）和极低反应性（CBA/HN）的近交系小鼠亲本品系产生的F1、F2和回交后代中，评估了对III型肺炎球菌多糖（SSS-III）的IgM抗体反应。这些研究结果表明，参与抗体反应的一个主要成分是X连锁的，即在X染色体上携带；该成分以几乎定量或“全有或全无”的方式决定对SSS-III的反应性。其他因素，大概是常染色体基因，调节具有X连锁基因的小鼠产生的抗体反应的强度；这些因素似乎独立影响免疫后发现的抗体产生细胞的数量以及此类细胞产生的抗体量。近交系小鼠品系对SSS-III的反应能力差异很大。反应性与H-2组织相容性类型无关。讨论了这些发现对SSS-III抗体反应的遗传控制的意义。
