Grundbacher F J
Science. 1972 Apr 21;176(4032):311-2. doi: 10.1126/science.176.4032.311.
Concentrations of immunoglobulin M in serum were one-third higher in females than in males in the Black and White populations of Virginia. In family studies, a much closer correlation was shown between boys and their mothers than between boys and their fathers. The immunoglobulin M concentrations in girls were more closely correlated with those of their fathers than with those of their mothers. The higher mean values for IgM in females and the relative magnitudes of the correlation coefficients between parents and offspring support the hypothesis that the X chromosome of man carries genes with an effect on IgM concentration. These patterns were not demonstrated for immunoglobulins A or G.
在弗吉尼亚州的黑人和白人人群中，血清免疫球蛋白M的浓度女性比男性高1/3。在家族研究中，男孩与其母亲之间的相关性比男孩与其父亲之间的相关性更为密切。女孩的免疫球蛋白M浓度与其父亲的相关性比与其母亲的相关性更为密切。女性IgM的较高平均值以及亲子之间相关系数的相对大小支持了这样一种假说，即人类的X染色体携带着对IgM浓度有影响的基因。免疫球蛋白A或G并未表现出这些模式。
