药物性再生障碍性贫血患者的骨髓移植
Bone marrow transplantation in a patient with drug-induced aplastic anemia.
作者信息
Banerjee T K, Band P R, Pabst H, Goldsand G, Armstrong W D, Brown J, Hill J R, Dossetor J B
出版信息
Can Med Assoc J. 1972 Sep 9;107(5):409-13.
A 23-year-old woman gravely ill with Pseudomonas septicemia secondary to presumed drug-induced bone marrow aplasia received marrow transplantation from two male HL-A identical sibling donors. She had a successful engraftment with excellent but temporary clinical improvement. Subsequently she succumbed to graft-versus-host disease manifested by Pseudomonas and Candida albicans septicemia, cytomegalovirus pneumonitis, three phases of dermatitis, nausea, vomiting, dysphagia, diarrhea, fever, edema and bone pain, with gradual but complete graft suppression by the 74th day after the transplantation. A second marrow transplant on the 70th day was unsuccessful.
一名23岁女性因推测药物性骨髓再生障碍继发假单胞菌败血症而病情严重，接受了来自两名HL-A相同的男性同胞供体的骨髓移植。她成功植入，临床有显著但短暂的改善。随后，她死于移植物抗宿主病，表现为假单胞菌和白色念珠菌败血症、巨细胞病毒肺炎、三期皮炎、恶心、呕吐、吞咽困难、腹泻、发热、水肿和骨痛，移植后第74天移植物逐渐但完全受抑制。第70天进行的第二次骨髓移植未成功。
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