Royal A, Garapin A, Cami B, Perrin F, Mandel J L, LeMeur M, Brégégègre F, Gannon F, LePennec J P, Chambon P, Kourilsky P
Nature. 1979 May 10;279(5709):125-32. doi: 10.1038/279125a0.
Two large DNA fragments overlapping the chicken ovalbumin gene have been isolated by molecular cloning. Analysis of these fragments provided a map of a 46,000-base pair region of the chicken genome. This region contains the complete ovalbumin gene (including its mRNA leader-coding sequence) and at least two other genes of unknown function. All three genes are orientated in the same direction and their expression in chicken oviduct is under hormonal control. The three genes share some sequence homologies, suggesting that duplications have occurred in the ovalbumin gene region in the course of evolution.
通过分子克隆分离出了两个与鸡卵清蛋白基因重叠的大DNA片段。对这些片段的分析提供了鸡基因组一个46000碱基对区域的图谱。该区域包含完整的卵清蛋白基因（包括其mRNA前导编码序列）以及至少两个功能未知的其他基因。所有这三个基因都朝同一方向排列，并且它们在鸡输卵管中的表达受激素控制。这三个基因具有一些序列同源性，表明在进化过程中卵清蛋白基因区域发生了重复。
