Rose A M, Baillie D L
Genetics. 1980 Nov;96(3):639-48. doi: 10.1093/genetics/96.3.639.
In the nematode Caenorhabditis elegans mutants in the gene unc-15 (I) affect the muscle protein paramyosin (Waterston, Fishpool and Brenner 1977). We have characterized 20 ethyl methanesulfonate-induced mutations in essential genes closely linked to unc-15. These lethals defined 16 new complementation groups. In the 0.65 map-unit interval around unc-15 defined by dpy-14 and unc-56, seven newly identified genes have been mapped relative to five existing genes. At present, the average distance between genes in this region is approximately 0.05 map units. Two genes, unc-15 and unc-13, are only 0.025 map units apart. Partial fine-structures maps of alleles of these two genes have been constructed. This analysis of unc-15 and genes adjacent to it is the first in a series of genetic and biochemical studies directed towards understanding the control of unc-15 expression.
在线虫秀丽隐杆线虫中，unc-15（I）基因的突变会影响肌肉蛋白副肌球蛋白（沃特斯顿、菲什普尔和布伦纳，1977年）。我们已经鉴定了20个与unc-15紧密连锁的必需基因中的甲磺酸乙酯诱导突变。这些致死突变定义了16个新的互补群。在由dpy-14和unc-56定义的unc-15周围0.65个图距单位区间内，相对于五个现有基因，已经定位了七个新鉴定的基因。目前，该区域基因之间的平均距离约为0.05个图距单位。两个基因unc-15和unc-13相距仅0.025个图距单位。已经构建了这两个基因等位基因的部分精细结构图谱。对unc-15及其相邻基因的这种分析是旨在理解unc-15表达调控的一系列遗传和生化研究中的第一项。
