移植物抗白血病：小鼠白血病过继性免疫治疗的定量分析
Graft versus leukemia: quantification of adoptive immunotherapy in murine leukemia.
作者信息
Bortin M M, Rimm A A, Saltzstein E C
出版信息
Science. 1973 Feb 23;179(4075):811-3. doi: 10.1126/science.179.4075.811.
PMID:4405359
Abstract
Quantification of the antileukemic reactivity of transplanted immunocompetent cells from various allogeneic donors was achieved against a long-passage lymphocytic leukemia of AKR mice. Adoptive immunotherapy was the exclusive antileukemic treatment. Cells from DBA/2 donors exhibited maximal antileukemic effect, inactivating up to an estimated 10(7) leukemia cells. The cellular events were interpreted by using a theoretical cytokinetic construct.
摘要
针对AKR小鼠的长期传代淋巴细胞白血病，实现了对来自不同同种异体供体的移植免疫活性细胞的抗白血病反应性的定量分析。过继性免疫疗法是唯一的抗白血病治疗方法。来自DBA/2供体的细胞表现出最大的抗白血病作用，可使多达估计10(7)个白血病细胞失活。利用理论细胞动力学结构对细胞事件进行了解释。
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