Roszkowska W, Worowski K
Acta Haematol Pol. 1979 Oct;10(4):291-8.
Histones form insoluble complexes with heparin and neutralize its anticoagulant action. The plasmin degradation products of histones do not possess these properties. Plasmin also digests histones in complexes with heparin. Breakdown of the histones in these complexes causes release of heparin from them.
组蛋白与肝素形成不溶性复合物并中和其抗凝作用。组蛋白的纤溶酶降解产物不具有这些特性。纤溶酶也会消化与肝素结合的组蛋白。这些复合物中组蛋白的分解导致肝素从中释放出来。
