Aycock N R, Jollie W P, Dunn L J
Obstet Gynecol. 1979 May;53(5):565-71.
Although electron microscopy has been of limited value in detecting malignant neoplasms, some neoplasms do exhibit characteristic ultrastructural features. Intensive study of these features may offer insight into the etiology and activity of such tumors. In an attempt to characterize the ultrastructure of endometrial adenocarcinoma, tissue was examined with the electron microscope and compared with normal postmenopausal endometrium. Endometria from biopsy, hysterectomy, or curettage were processed routinely for light and electron microscopy. Several ultrastructural features of the adenocarcinoma were common both to previous descriptions of endometrium of the postovulatory phase and to the normal postmenopausal endometrium, described here, viz, atypical mitochondrial forms and cell surface modifications. Ribosomes were abundant in adenocarcinoma of the endometrium, normal postmenopausal endometrium, and normal cyclic endometrium in the preovulatory phase.
尽管电子显微镜在检测恶性肿瘤方面价值有限，但一些肿瘤确实呈现出特征性的超微结构特征。对这些特征进行深入研究可能有助于深入了解此类肿瘤的病因和活性。为了描述子宫内膜腺癌的超微结构，我们用电子显微镜对组织进行了检查，并与绝经后正常子宫内膜进行了比较。取自活检、子宫切除术或刮宫术的子宫内膜常规处理后用于光学显微镜和电子显微镜检查。腺癌的几个超微结构特征既与先前对排卵后期子宫内膜的描述相同，也与本文所述的绝经后正常子宫内膜相同，即非典型线粒体形态和细胞表面改变。核糖体在子宫内膜腺癌、绝经后正常子宫内膜以及排卵前期正常周期性子宫内膜中均大量存在。
