Ruoslahti E, Salaspuro M, Pihko H, Andersson L, Seppälä M
Br Med J. 1974 Jun 8;2(5918):527-9. doi: 10.1136/bmj.2.5918.527.
Raised serum alpha-fetoprotein levels measured by radioimmunoassay were found in 19 out of 24 (79%) patients with primary liver cancer and in 32 out of 311 (10%) patients with other liver diseases. The rise was transient in cases of hepatitis and a transient rise was also seen after alcohol intake ceased in two patients with cirrhosis. alpha-Fetoprotein levels exceeding 500 ng/ml were 30-50 times more common in primary liver cancer than in other liver diseases. A rise in level seems to reflect the extent of liver regeneration in liver diseases other than primary cancer.
通过放射免疫测定法测得，24例原发性肝癌患者中有19例（79%）血清甲胎蛋白水平升高，311例其他肝病患者中有32例（10%）血清甲胎蛋白水平升高。肝炎患者的甲胎蛋白升高是暂时的，两名肝硬化患者在戒酒之后也出现了甲胎蛋白水平的暂时升高。原发性肝癌患者甲胎蛋白水平超过500纳克/毫升的情况比其他肝病患者多30至50倍。甲胎蛋白水平升高似乎反映了除原发性癌症之外其他肝病中的肝脏再生程度。
