桥本甲状腺炎和格雷夫斯病中甲状腺球蛋白抗体的定性方面。
Qualitative aspects of thyroglobulin antibodies in Hashimoto's thyroiditis and Graves' disease.
作者信息
Dussault J H, Guay D
出版信息
Can Med Assoc J. 1974 Aug 17;111(4):319-22.
We have tried to characterize the thyroglobulin antibodies (TgAb) involved in Hashimoto's thyroiditis and Graves' disease by studying their affinity constants and binding capacities. Two populations of antibodies were found in half of the patients with either disease, TgAb(1) with a high affinity (K(1)) but a low binding capacity (B(1)) and TgAb(2) with a lower affinity (K(2)) but a much higher binding capacity (B(2)). The mean affinity constants and binding capacities were similar in the two diseases. In the other half of the patients only one population of antibody was present, with a low affinity constant (K(t)) and a very high binding capacity (B(t)), thus comparable to TgAb(2). The mean K(t) and B(t) were similar in the two diseases. From these results it would appear that circulating thyroglobulin antibodies in Hashimoto's thyroiditis and Graves' disease are similar in their affinity constants and binding capacities, so that these characteristics do not reflect the different pathogenesis of each condition.
我们试图通过研究甲状腺球蛋白抗体（TgAb）的亲和常数和结合能力来表征参与桥本甲状腺炎和格雷夫斯病的甲状腺球蛋白抗体。在这两种疾病的半数患者中发现了两类抗体，一类是具有高亲和力（K(1)）但低结合能力（B(1)）的TgAb(1)，另一类是具有较低亲和力（K(2)）但高得多的结合能力（B(2)）的TgAb(2)。这两种疾病的平均亲和常数和结合能力相似。在另一半患者中仅存在一类抗体，其具有低亲和常数（K(t)）和非常高的结合能力（B(t)），因此与TgAb(2)相当。这两种疾病的平均K(t)和B(t)相似。从这些结果来看，桥本甲状腺炎和格雷夫斯病中的循环甲状腺球蛋白抗体在亲和常数和结合能力方面似乎相似，因此这些特征并不能反映每种疾病的不同发病机制。
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