Gober A E, Kearns G L, Yokel R A, Danziger L
Pediatrics. 1979 Apr;63(4):606-8.
Repeated injections of naloxone by hydrochloride, a pure narcotic antagonist, were administered to a 3,320-gm 4-week-old boy for treatment of an accidental morphine overdose. The infant received frequent naloxone hydrochloride injections (0.2 mg per injection) during the first 12 hours of therapy to reverse morphine-induced apnea, hypothermia, and flaccidity. A cumulative dose of 2.73 mg of naloxone hydrochloride (0.822 mg/kg) was administered over 27 hours without apparent adverse effect or evidence of toxicity.
对一名体重3320克、4周大的男婴反复注射盐酸纳洛酮（一种纯麻醉拮抗剂），以治疗意外吗啡过量。在治疗的前12小时内，该婴儿频繁接受盐酸纳洛酮注射（每次0.2毫克），以逆转吗啡引起的呼吸暂停、体温过低和肌肉松弛。在27小时内累计给予2.73毫克盐酸纳洛酮（0.822毫克/千克），未出现明显不良反应或毒性迹象。
