利用磷-31核磁共振对核酸磷酸酯键进行的构象研究。
A conformational study of nucleic acid phosphate ester bonds using phosphorus-31 nuclear magnetic resonance.
作者信息
Haasnoot C A, Altona C
出版信息
Nucleic Acids Res. 1979 Mar;6(3):1135-49. doi: 10.1093/nar/6.3.1135.
Abstract
A systematic phosphorus-31 nuclear magnetic resonance study of some nucleic acid constituents (6-N-(dimethyl)adenylyl-(3',5')-uridine and some nucleotide methyl esters) is presented. The temperature dependent phosphorus-31 chemical shifts were analyzed by standard thermodynamic procedures. It is shown that gt conformations about the P-O ester bonds have a lower free energy content relative to gg conformers.
摘要
本文介绍了对一些核酸成分（6-N-（二甲基）腺苷基-（3'，5'）-尿苷和一些核苷酸甲酯）进行的系统磷-31核磁共振研究。通过标准热力学程序分析了温度依赖性磷-31化学位移。结果表明，相对于gg构象，P-O酯键周围的gt构象具有较低的自由能含量。
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The nature of stacking equilibria in polynucleotides.多核苷酸中堆积平衡的本质。
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