Sale G E, Shulman H M, McDonald G B, Thomas E D
Am J Surg Pathol. 1979 Aug;3(4):291-9. doi: 10.1097/00000478-197908000-00001.
Evaluation of the diagnostic utility of the rectal biopsy in graft-versus-host disease (GVHD), using the crypt abscess as a major diagnostic criterion, was based on 52 patients who had received marrow allografts for leukemia or aplastic anemia. Thirty-six of these patients had acute GVHD by skin biopsy criteria. These 36 patients demonstrated a strong association of the rectal crypt abscess with severity of clinical GVHD. High stool volume also correlated strongly with the crypt abscess. Patients without clear evidence of GVHD usually had normal rectal histology. Serial studies showed a good correlation of rectal biopsy results with the clinical course of acute GVHD. Patients with chronic GVHD had rectal mucosal damage only during the acute phase. Rectal ileal and cecal disease accurately. The rectal biopsy is a useful adjunct to serial skin biopsies in the diagnosis of GVHD in man.
以隐窝脓肿作为主要诊断标准，对直肠活检在移植物抗宿主病（GVHD）中的诊断效用进行评估，该评估基于52例因白血病或再生障碍性贫血接受骨髓同种异体移植的患者。根据皮肤活检标准，这些患者中有36例患有急性GVHD。这36例患者显示直肠隐窝脓肿与临床GVHD的严重程度密切相关。高粪便量也与隐窝脓肿密切相关。没有明确GVHD证据的患者直肠组织学通常正常。系列研究表明直肠活检结果与急性GVHD的临床病程具有良好的相关性。慢性GVHD患者仅在急性期有直肠黏膜损伤。直肠、回肠和盲肠疾病准确。直肠活检是对人体GVHD进行诊断时对系列皮肤活检的有用辅助手段。
