Ambrosch F, Königstein R P, Olbrich E, Potschka W, Wiedermann G
Aktuelle Gerontol. 1979 Sep;9(9):399-404.
207 patients of a geriatric department were immunized against influenza with either tween-ether-split-vaccine or subunit-vaccine in a double blind study. For 6 months the following data were daily registered: rest in bed, fever over 38,5 degrees C, rhinitis, laryngopharingitis, bronchitis, pneumonia, enteritis, medication with antibiotics or chemotherapeutics. In cases with fever over 38,5 degrees C blood tests were taken for serological examination. The immune response against influenza A was excellent in both groups, the titer was higher in the subunit group, only one patient showed influenza infection. The immune response against the type B Hongkong was not satisfactory in both groups. The clinical data showed a significant lower incidence of rhinitis, laryngopharingitis and bronchitis in the group immunized with the tween-ether-split-vaccine. This effect was more distinct within the first 3 months after the immunization than within the second 3 months.
在一项双盲研究中，对某老年科的207名患者使用吐温 - 乙醚裂解疫苗或亚单位疫苗进行流感免疫接种。在6个月的时间里，每天记录以下数据：卧床休息情况、体温超过38.5摄氏度、鼻炎、喉咽炎、支气管炎、肺炎、肠炎、使用抗生素或化疗药物的情况。对于体温超过38.5摄氏度的病例，进行血液检测以进行血清学检查。两组对甲型流感的免疫反应都很好，亚单位组的滴度更高，只有一名患者出现流感感染。两组对乙型香港流感的免疫反应都不令人满意。临床数据显示，使用吐温 - 乙醚裂解疫苗免疫的组中，鼻炎、喉咽炎和支气管炎的发病率显著较低。这种效果在免疫后的前3个月比后3个月更明显。
