Danielczyk W
Aktuelle Gerontol. 1979 Sep;9(9):427-31.
23.3 per cent out of 180 old patients (age above 60 years, 71 y in the mean) suffering from chronic cerebral disorders (3 large groups of disease) developed pharmacotoxic psychoses. This relative high percentage can be explained by psychotoxic side effects of the modern antiparkinson-therapy. The incidence to psychotoxicity of combined L-Dopa seems to be less marked in patients without Parkinson's disease when compared to patients with progredient nigrostriatal degeneration. Toxic delirium as a result of treatment with antidepressants, diuretics and digitalis was observable only in a few percentage. This occurance was even less pronounced in comparison to acute developing exogene psychoses in the same group of patients when drugs were not administered.
180名老年患者（年龄在60岁以上，平均71岁）患有慢性脑部疾病（3大类疾病），其中23.3%出现了药物中毒性精神病。这一相对较高的比例可以用现代抗帕金森治疗的精神毒性副作用来解释。与患有进行性黑质纹状体变性的患者相比，联合使用左旋多巴时，无帕金森病患者的精神毒性发生率似乎不那么明显。仅在少数百分比的患者中观察到因使用抗抑郁药、利尿剂和洋地黄治疗导致的中毒性谵妄。与同一组未用药时急性发生的外源性精神病相比，这种情况甚至更不明显。
