Northway M G, Libshitz H I, West J J, Withers H R, Mukhopadhyay A K, Osborne B M, Szwarc I A, Dodd G D
Radiology. 1979 Jun;131(3):731-5. doi: 10.1148/131.3.731.
Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, four animals received 60Co radiation of various doses; two served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography, and manometry were performed. Esophagitis developed at one week in irradiated animals. Opossums receiving 17.5, 20, and 22.5 Gy (1,750; 2,000; and 2,250 rad) became anorexic one week postirradiation, and abnormal motility subsequently developed. The controls and the animal receiving 15 Gy (1,500 rad) remained normal. Histological changes in the irradiated opossum esophagus resembled those found in humans.
六只负鼠被评估作为放射性食管炎的一种可能动物模型。在对食管进行单次照射时，四只动物接受了不同剂量的钴 - 60辐射；两只作为对照。使用纤维内镜、黏膜活检、食管钡餐造影和测压法进行照射前和照射后的评估。照射动物在一周后出现食管炎。接受17.5、20和22.5戈瑞（1750、2000和2250拉德）的负鼠在照射一周后出现厌食，随后出现异常蠕动。对照组和接受15戈瑞（1500拉德）的动物保持正常。照射后的负鼠食管组织学变化与人类相似。
