Chowhan N M
Department of Medicine, State University of New York, Stony Brook.
Am J Gastroenterol. 1990 Feb;85(2):115-20.
Esophageal damage secondary to radiation therapy to thoracic tumors is a major dose limiting complication. Concomitant use of chemotherapeutic agents enhance this problem which can appear as esophagitis early in the course of treatment or as strictures later. Early complications usually are treated conservatively, whereas endoscopic dilatations of the esophagus are often used for strictures. Newer developments in the field include use of arachidonic acid metabolism pathway inhibitors and radioprotectants. The use of these pharmacologicals, together with modification of the mechanics of radiation delivery, may lead us close to elimination of the complications in normal esophageal tissue, while enhancing localized response in the thoracic tumors.
胸部肿瘤放射治疗继发的食管损伤是一种主要的剂量限制性并发症。同时使用化疗药物会加剧这一问题，其表现可能为治疗早期的食管炎或后期的狭窄。早期并发症通常采用保守治疗，而食管狭窄则常使用内镜扩张术。该领域的新进展包括使用花生四烯酸代谢途径抑制剂和辐射防护剂。这些药物的使用，再加上对放射治疗机制的改进，可能会使我们接近于消除正常食管组织中的并发症，同时增强胸部肿瘤的局部反应。
