Tse J, Coceani F
Prostaglandins. 1979 Jan;17(1):71-7. doi: 10.1016/0090-6980(79)90076-5.
15-Methyl prostaglandin E2, a compound which is not a substrate for 15-hydroxy prostaglandin dehydrogenase, is a more potent pyretic agent than prostaglandin E2 when injected into the third ventricle of conscious cats. This finding raises the possibility that 15-hydroxy prostaglandin dehydrogenase contributes to prostaglandin inactivation in brain, notwithstanding its low activity.
15-甲基前列腺素E2，一种不是15-羟基前列腺素脱氢酶作用底物的化合物，当注入清醒猫的第三脑室时，它作为发热剂比前列腺素E2更有效。这一发现增加了一种可能性，即尽管15-羟基前列腺素脱氢酶活性较低，但它仍有助于大脑中前列腺素的失活。
