大鼠脑匀浆对前列腺素的代谢作用
On the metabolism of prostaglandins by rat brain homogenate.
作者信息
Kröner E E, Peskar B A
出版信息
Experientia. 1976 Sep 15;32(9):1114-5. doi: 10.1007/BF01927575.
PMID:971735
Abstract
Using radio-immuno assays for prostaglandins and prostaglandin metabolites, three prostaglandin metabolizing enzymes were found in the 100,000 X g supernatant of rat brain, 15-hydroxy-prostaglandin-dehydrogenase, delta13-reductase and prostaglandin E-9-keto-reductase. Specific activity of the latter enzyme was highest in striatum and midbrain and lowest in cortex, cerebellum and spinal cord.
摘要
利用前列腺素和前列腺素代谢物的放射免疫分析法，在大鼠脑100,000×g上清液中发现了三种前列腺素代谢酶，即15-羟基前列腺素脱氢酶、δ13-还原酶和前列腺素E-9-酮还原酶。后一种酶的比活性在纹状体和中脑中最高，在皮质、小脑和脊髓中最低。
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