小鼠的癌症生长、对治疗的反应及存活时间：前列腺素合成抑制剂氟比洛芬的有益作用
Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen.
作者信息
Bennett A, Houghton J, Leaper D J, Stamford I F
出版信息
Prostaglandins. 1979 Feb;17(2):179-91. doi: 10.1016/0090-6980(79)90037-6.
PMID:441430
Abstract
Adult mice were injected subcutaneously with cells from a syngeneic metastasizing mammary cancer. Daily treatment with flurbiprofen starting before injection of the cancer cells reduced tumour growth and lengthened the survival of mice whose tumours were excised at 3 weeks. When low doses of radiotherapy and chemotherapy were given, additional treatment with flurbiprofen starting 25 days after injecting the cancer cells substantially inhibited tumour growth.
摘要
将同基因转移性乳腺癌细胞皮下注射到成年小鼠体内。在注射癌细胞之前开始每日使用氟比洛芬进行治疗，可减少肿瘤生长，并延长在3周时切除肿瘤的小鼠的生存期。当给予低剂量放疗和化疗时，在注射癌细胞25天后开始额外使用氟比洛芬治疗，可显著抑制肿瘤生长。
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Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen.小鼠的癌症生长、对治疗的反应及存活时间：前列腺素合成抑制剂氟比洛芬的有益作用
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